36999-43-6

Basic information

• Product Name: Ethyl2-amino-2-(2-phenylhydrazono)acetate
• Synonyms: Ethyl2-amino-2-(2-phenylhydrazono)acetate
• CAS NO: 36999-43-6
• Molecular Formula: C₁₀H₁₃N₃O₂
• Molecular Weight: 207.22912
• Mol File: 36999-43-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 328.7°C at 760 mmHg
• Flash Point: 152.6°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.000186mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: Ethyl2-amino-2-(2-phenylhydrazono)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl2-amino-2-(2-phenylhydrazono)acetate(36999-43-6)
• EPA Substance Registry System: Ethyl2-amino-2-(2-phenylhydrazono)acetate(36999-43-6)

Safety Data

• Hazardous Substances Data: 36999-43-6(Hazardous Substances Data)

Usage

General Description

Ethyl 2-amino-2-(2-phenylhydrazono)acetate is a chemical compound with the molecular formula C10H13N3O2. It is a hydrazone derivative of ethyl glycinate and is commonly used in organic synthesis and pharmaceutical research. Ethyl2-amino-2-(2-phenylhydrazono)acetate has potential applications in the development of drugs and bioactive molecules due to its unique chemical structure and reactivity. It may also have potential use as a reagent for the synthesis of various organic compounds and as a building block for the preparation of new chemical entities. Further research and testing are necessary to fully understand the potential uses and properties of ethyl 2-amino-2-(2-phenylhydrazono)acetate.

InChI:InChI=1/C10H13N3O2/c1-2-15-10(14)9(11)13-12-8-6-4-3-5-7-8/h3-7,12H,2H2,1H3,(H2,11,13)

Upstream product

• 35257-03-5 N-phenylhydrazono α-bromoglyoxylate d'ethyle 
• 28663-68-5 ethyl (phenylhydrazono)chloroacetate 
• 898-22-6 triethyl 1,3,5-triazine-2,4,6-tricarboxylate 
• 100-63-0 phenylhydrazine 
• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 28663-68-5 ethyl chloro(2-phenylhydrazono)acetate 
• 6415-38-9 benzenediazonium sulphate 

Downstream Products

• 1105634-65-8 ethyl 1-phenyl-5-(trichloromethyl)-1H-1,2,4-triazole-3-carboxylate 
• 244795-13-9 ethyl 5-benzyl-1-phenyl-1H-1,2,4-triazole-3-carboxylate 
• 67267-08-7 ethyl 5-oxo-1-phenyl-4,5-dihydro-1H-1,2,4-triazole-3-carboxylate 

Relevant articles and documents

Monoacylglycerol Lipase Modulators

Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R2, R3 R4, R5 and R6 are defined herein.

Facile, diversity-orientated one-pot synthesis of ethyl 1,5-disubstituted-1H-1,2,4-triazole-3-carboxylates

Access to the 1,5-disubstituted-1H-1,2,4-triazole-3-carboxamide motif is quite laborious and requires forcing conditions to effect the cyclocondensation step. Herein, we report an efficient and mild one-pot protocol to access this substructure in good che

Diheteroarylmethanes. 8.1 Mapping charge and electron-withdrawing power of the 1,2,4-triazol-5-yl substituent

Three new triazolyl derivatives, bis(1H-1-phenyl-1,2,4-triazol-5- yl)methane (11), 1H-1-phenyl-5-(β-styryl)-1,2,4-triazole (12), and 1H-5- benzyl-1-phenyl-1,2,4-triazole (13) have been synthesized and the carbanions 11- and 13- investigated in DMSO by multinuclear NMR spectroscopy. By applying previously proposed and widely used π-charge/13C shift relationships on the spectra of the anions, it is possible to rank the π electron-withdrawing power of the 1,2,4-triazol-5-yl group in terms of charge demand c(X), a quantity that represents the fraction of π negative charge delocalized by the heterocyclic ring. Our results indicate that the charge demand c(X) of this heterocycle is considerably greater than that of other 1,3-azoles (2-imidazolyl, 2-oxazolyl, 2-benzoimidazolyl), being close to that of some mono- and diazinyl substituents. A single set of resonances is presented by both carbanions 11- and 13-, thus showing that they exist either as a single geometric isomer species or as a mixture of isomers in a rapid (on the NMR time scale) equilibrium, 13C and 15N shift/π-charge relationships allow accurate π-charge mapping of carbanionic systems. Our results clearly show that, in the case of benzyl carbanion 13-, all of the three nitrogen atoms are almost equally involved in delocalizing the negative charge. Also, the N-phenyl group contributes to charge delocalization. Anion 11- is the first of the bis(heteroaryl)methyl carbanions that we have studied, in which all of the negative charge originated by deprotonation of the carbon acid 11 is hosted on the nitrogen atoms without any appreciable involvement of the heteroaromatic carbon frame.