36999-88-9

Basic information

• Product Name: 4-thiadiazol-2-amine,5,5’-dithiobis-3
• Synonyms: 4-thiadiazol-2-amine,5,5’-dithiobis-3;5,5'-Dithiobis(1,3,4-thiadiazol-2-amine)
• CAS NO: 36999-88-9
• Molecular Formula: C₄H₄N₆S₄
• Molecular Weight: 0
• Mol File: 36999-88-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 585.3°Cat760mmHg
• Flash Point: 307.8°C
• Appearance: /
• Density: 1.93g/cm³
• CAS DataBase Reference: 4-thiadiazol-2-amine,5,5’-dithiobis-3(CAS DataBase Reference)
• NIST Chemistry Reference: 4-thiadiazol-2-amine,5,5’-dithiobis-3(36999-88-9)
• EPA Substance Registry System: 4-thiadiazol-2-amine,5,5’-dithiobis-3(36999-88-9)

Safety Data

• Hazardous Substances Data: 36999-88-9(Hazardous Substances Data)

Upstream product

• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 
• 2349-67-9 5-amino-2,3-dihydro-1,3,4-thiadiazole-2-thione 

Downstream Products

• 2349-67-9 5-amino-2,3-dihydro-1,3,4-thiadiazole-2-thione 

Relevant articles and documents

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes

Fructose-1,6-bisphosphatase (FBPase), as a key rate-limiting enzyme in the gluconeogenesis (GNG) pathway, represents a practical therapeutic strategy for type 2 diabetes (T2D). Our previous work first identified cysteine residue 128 (C128) was an important allosteric site in the structure of FBPase, while pharmacologically targeting C128 attenuated the catalytic ability of FBPase. Herein, ten approved cysteine covalent drugs were selected for exploring FBPase inhibitory activities, and the alcohol deterrent disulfiram displayed superior inhibitory efficacy among those drugs. Based on the structure of lead compound disulfiram, 58 disulfide-derived compounds were designed and synthesized for investigating FBPase inhibitory activities. Optimal compound 3a exhibited significant FBPase inhibition and glucose-lowering efficacy in vitro and in vivo. Furthermore, 3a covalently modified the C128 site, and then regulated the N125–S124–S123 allosteric pathway of FBPase in mechanism. In summary, 3a has the potential to be a novel FBPase inhibitor for T2D therapy.

HETEROARYL DISULFIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR INCREASING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN

This invention relates to compounds of Formula I: (Formula I), and pharmaceutically acceptable salt thereof, which are allosteric effectors that increase the oxygen-being affinity of hemoglobin, which are useful in the treatment of sickle cell disease, high altitude tissue hypoxia, and other conditions.

Bovine serum albumin triggered waste-free aerobic oxidative coupling of thiols into disulphides on water: An extended synthesis of bioactive dithiobis(phenylene)bis(benzylideneimine) via sequential oxidative coupling-condensation reactions in one pot from aminothiophenol and benzaldehyde

Bovine serum albumin (BSA) has been explored for aerobic oxidative coupling of thiols (aromatic, heterocyclic as well as aliphatic) "on water" towards formation of disulphides (SS) without using any metal/non-metal complexes, bases and additives, which renders the process environmentally benign and economically attractive with good recyclability (up to four cycles). The developed green protocol was further extended for synthesis of diallyldisulphide (DADS), an important constituent of natural occurring allicin. Among various synthesized disulphides, bis(2-aminophenyl)disulphide, obtained by oxidative coupling of 2-aminothiophenol in BSA, was further utilized for condensation with benzaldehyde in the same pot thus enabling easy access to bioactive dithiobis(phenylene)bis(benzyldeneimine). This is the first example of BSA catalysed sequential (oxidation/condensation) reaction where one SS and two CN bonds are formed solely "on water."