37096-14-3Relevant articles and documents
Synthesis of (3′R,5′S)-3′-hydroxycotinine using 1,3-dipolar cycloaddition of a nitrone
Tamura, Osamu,Kanoh, Ayano,Yamashita, Masayuki,Ishibashi, Hiroyuki
, p. 9997 - 10003 (2007/10/03)
To synthesize (3′R,5′S)-3′-hydroxycotinine [(+)-1], the main metabolite of nicotine (2), cycloaddition of C-(3-pyridyl)nitrones 3a, 3c, and 15 with (2R)- and (2S)-N-(acryloyl)bornane-10,2-sultam [(2R)- and (2S)-8] was examined. Among them, l-gulose-derived nitrone 15 underwent stereoselective cycloaddition with (2S)-8 to afford cycloadduct 16, which was elaborated to (+)-1. Graphical Abstract
METABOLIC STUDIES WITH MODEL CYTOCHROME p-450 SYSTEMS
Chauncey, M. A.,Ninomiya, Shin-ichi
, p. 5901 - 5904 (2007/10/02)
The biomimetic potential of metalloporphyrin catalysts has been studied using nicotine as the substrate.Results indicate the formation of products identical to those obtained from in vivo metabolism.