3717-22-4

Basic information

• Product Name: 4-METHOXY-BENZALDEHYDE OXIME
• Synonyms: (Z)-4-Methoxybenzaldehyde oxime;4-Methoxybenzaldehyde (Z)-oxime;N-[(4-methoxyphenyl)methylidene]hydroxylamine;p-methoxybenzaldehyde oxime
• CAS NO: 3717-22-4
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• Mol File: 3717-22-4.mol
• Article Data: 198

Chemical Properties

• Boiling Point: 247.4°Cat760mmHg
• Flash Point: 103.4°C
• Appearance: /
• Density: 1.07g/cm³
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-METHOXY-BENZALDEHYDE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-BENZALDEHYDE OXIME(3717-22-4)
• EPA Substance Registry System: 4-METHOXY-BENZALDEHYDE OXIME(3717-22-4)

Safety Data

• Hazardous Substances Data: 3717-22-4(Hazardous Substances Data)

Usage

General Description

4-Methoxy-benzaldehyde oxime is a chemical compound that belongs to the class of organic oxime esters. It is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceuticals. This chemical is also used in the synthesis of organic compounds and as a reagent in organic transformations. It has potential applications in the production of agrochemicals, flavors, fragrances, and other fine chemicals. Additionally, 4-Methoxy-benzaldehyde oxime has been studied for its antitumor and antibacterial properties, indicating its potential as a bioactive compound for medicinal purposes. Overall, this compound has a wide range of industrial and research applications due to its chemical properties and potential biological activities.

Upstream product

• 115828-61-0 4-methoxy-benzaldehyde-(O-picryl-seqtrans-oxime ) 
• 124-41-4 sodium methylate 
• 75-52-5 nitromethane 
• 100-66-3 methoxybenzene 
• 22755-24-4 sodium salt of nitromethane 
• 123-11-5 4-methoxy-benzaldehyde 
• 67-56-1 methanol 
• 104-93-8 p-methylanizole 
• 60-29-7 diethyl ether 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 1517-45-9 4-methoxy-benzaldehyde-((Z)-O-acetyl oxime ) 
• 141-78-6 ethyl acetate 
• 92114-96-0 mercury fulminate 

Downstream Products

• 17975-46-1 3-methyl-4-(4-methoxyphenyl)methyleneisoxazole-5(4H)-one 
• 95317-74-1 6,7-dimethoxy-1-(4-methoxy-phenyl)-3-methyl-3,4-dihydro-isoquinoline 
• 3717-21-3 (E)-4-methoxybenzaldoxime 
• 2393-23-9 4-methoxy-benzylamine 
• 971-31-3 4-Methoxy-benzaldehyd- 
• 52629-35-3 O-Trimethylsilyl-p-methoxybenzaldoxim 
• 54222-76-3 C₁₈H₂₂N₂O₄Si 
• 89902-76-1 2-(2-cyanoethyl)-3-(p-methoxyphenyl)-5-cyanoisoxazolidine 
• 89902-76-1 2-(2-cyanoethyl)-3-(p-methoxyphenyl)-5-cyanoisoxazolidine 
• 89902-78-3 2-(2-cyanoethyl)-3-(p-methoxyphenyl)-4-cyanoisoxazolidine 
• 89902-78-3 2-(2-cyanoethyl)-3-(p-methoxyphenyl)-4-cyanoisoxazolidine 
• 874-90-8 4-methoxybenzonitrile 
• 7050-80-8 4-Methoxy-O-<2,4-dimethyl-phenoxycarbimidoyl>-benzaldoxim 
• 165277-87-2 1-(4-methoxyindanylideneaminoxy)-2,3-epoxypropane 

Relevant articles and documents

Visible-Light-Mediated Strategies for the Preparation of Oxime Ethers Derived from O-H Insertions of Oximes into Aryldiazoacetates

Two visible-light-mediated O-H insertion protocols involving oximes and aryldiazoacetates leading to different products depending on the solvent employed are reported. In DCM, direct O-H insertion takes place. In THF, there is the additional incorporation of the ring-opened form of this solvent into the structure of the product. These metal-free protocols are mild and tolerant to air and moisture. The preparation of an acaricide has been developed as an example of synthetic application.

Visible-light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes

A visible light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes to (E)-difluoroalkylated ketoximes has been described. In this reaction, (hetero)-aromatic and aliphatic difluoroalkylated ketoximes could be obtained with the retention of the configuration of the starting aldoximes. A preliminary mechanism study showed that a difluoromethyl radicalviaan SET pathway was involved.

On the mixed oxides-supported niobium catalyst towards benzylamine oxidation

A series of mixed oxides-supported niobium-based catalysts has been synthesized and applied towards oxidation reactions of benzylamine derivatives. Under the optimized reaction conditions, the selectivity to oxime enhanced, leading to the main product with up to 72 %. Moreover, even α-substituted benzylamines were well tolerated and led to oximes in good isolated yields. It is important to mention; four equivalents of the harmless and inexpensive hydrogen peroxide were employed as oxidizing agent. Mechanism hypothesis suggested that the reaction proceed to selective benzylamine oxidation into nitroso intermediate, following by formation of the corresponding oxime tautomer mediated by an unstable water produced by NbOx supported catalyst. This consists the first mixed oxides-supported niobium-based catalyst for selective oxidation of benzylamines to oximes.