371766-08-4

Basic information

• Product Name: Isoquinoline-5-boronic acid
• Synonyms: RARECHEM AK VD 0026;5-ISOQUINOLINEBORONIC ACID;5-ISOQUINOLINEBORONIC ACID, HCL;AKOS BRN-0458;ISOQUINOLIN-5-YLBORONIC ACID;ISOQUINOLIN-5-YLBORONIC ACID, HCL;ISOQUINOLIN-5-YLBORONIC ACID HYDROCHLORIDE;ISOQUINOLINE-5-BORONIC ACID
• CAS NO: 371766-08-4
• Molecular Formula: C₉H₈BNO₂
• Molecular Weight: 209.44
• EINECS: -0
• Product Categories: blocks;BoronicAcids;Quinolines;Quinoline&Isoquinoline;Boronic acid;Isoquinoline;Organoborons;Boronic Acids;Boronic Acids and Derivatives;Heteroaryl;Boric Acid| Boric Acid Ester| Potassium Trifluoroborate
• Mol File: 371766-08-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 204-206
• Boiling Point: 419.1 °C at 760 mmHg
• Flash Point: 207.3 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 2.32E-08mmHg at 25°C
• Storage Temp.: Keep Cold
• CAS DataBase Reference: Isoquinoline-5-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline-5-boronic acid(371766-08-4)
• EPA Substance Registry System: Isoquinoline-5-boronic acid(371766-08-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 371766-08-4(Hazardous Substances Data)

Usage

Uses

Isoquinoline-5-boronic acid, HCl

InChI:InChI=1/C9H8BNO2.ClH/c12-10(13)9-3-1-2-7-6-11-5-4-8(7)9;/h1-6,12-13H;1H

Upstream product

• 34784-04-8 5-bromoisoquinoline 
• 121-43-7 Trimethyl borate 
• 5419-55-6 Triisopropyl borate 
• 7732-18-5 water 

Downstream Products

• 1247828-26-7 methyl 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate 
• 1454667-26-5 tert-butyl 4-(2-(1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1454667-84-5 tert-butyl 4-(2-(2-(N-(pyrazin-2-yl)sulfamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1454666-73-9 N-(pyrazin-2-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide hydrochloride 
• 1454667-78-7 5-(2-(4-methyl-1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline 
• 1454666-62-6 N-(5-fluorothiazol-2-yl)-5-(2-(4-methyl-1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide 
• 1454667-66-3 tert-butyl 4-(2-(2-(N-(pyrimidin-4-yl)sulfamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1454666-57-9 N-(pyrimidin-4-yl)-5-(2-(1,2,3,6-tetrahydropyridin-4-yl)-4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide 
• 1454667-64-1 tert-butyl 4-(2-(2-(N-(thiazol-2-yl)sulfamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate 

Relevant articles and documents

NOVEL PYRIDIN-2(1H)ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF PAIN

The present invention concerns novel pyridin-2(1H)one derivatives, their process of preparation and their use in therapeutics, in particular as agents for treating and/or preventing pain.

Synthesis of nonsymmetrical 5-Aryl-2-indolopyrrole derivatives via controlled mono Suzuki-Miyaura cross-coupling on N-Boc-2,5-dibromopyrrole

The first example of mono Suzuki-Miyaura cross-coupling of N-Boc-2,5-dibromopyrrole with a boronic acid (indol-2-ylboronic acid) is reported. The resulting 2-indolyl-5-bromopyrrole derivative was in turn coupled with a variety of aryl- or heteroarylboronic acids thereby providing the corresponding non-symmetrical 2,5-disubstituted pyrroles in good to excellent yields. The tert-butoxycarbonyl (Boc) groups could be easily removed to give the completely deprotected products. Georg Thieme Verlag Stuttgart - New York.

BIARYLCARBOXYARYLAMIDES AS VANILLOID-1 RECEPTOR MODULATORS

The present invention provides compounds of formula (I): wherein A and Z are as defined in the description, along with methods for preparing such derivatives and their use for the treatment of inflammatory diseases such as neuropathic pain.