372-39-4

Basic information

• Product Name: 3,5-Difluoroaniline
• Synonyms: 3,5-DIFLUOROBENZENAMINE;3,5-DIFLUOROANILINE;3,5-Difluoroaniline(AntibacterialAntiphlogistic,WeedKiller)(C6H5F2N);3,5-Difluoroaniline,98%;3,5-Difluoroaniline 98%;3,5-DIFLUOROBENZENEAMINE;Benzenamine, 3,5-difluoro;3,5-Difluoronitroaniline
• CAS NO: 372-39-4
• Molecular Formula: C₆H₅F₂N
• Molecular Weight: 129.11
• EINECS: 206-752-8
• Product Categories: Fluorobenzene Series;Fluorobenzene;Anilines, Aromatic Amines and Nitro Compounds;Miscellaneous;Amines;C2 to C6;Nitrogen Compounds
• Mol File: 372-39-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 37-41 °C(lit.)
• Boiling Point: 80°C 20mm
• Flash Point: 167 °F
• Appearance: White to yellow/Low Melting Solid
• Density: 1,295 g/cm3
• Vapor Pressure: 0.7mmHg at 25°C
• Refractive Index: 1,512-1,514
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.57±0.10(Predicted)
• Water Solubility: Insoluble in water
• BRN: 2802286
• CAS DataBase Reference: 3,5-Difluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoroaniline(372-39-4)
• EPA Substance Registry System: 3,5-Difluoroaniline(372-39-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 28-36/37/39-26-36
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 8-10-23
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 372-39-4(Hazardous Substances Data)

Usage

Description

3,5-Difluoroaniline is a white to yellowish low melting solid that has been investigated for its in vitro nephrotoxic effects in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.

Uses

Used in Chemical Synthesis:
3,5-Difluoroaniline is used as a chemical intermediate for the preparation of 3,5-difluorodimethylaniline, which is an important compound in the synthesis of various pharmaceuticals and organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,5-difluoroaniline is used as a building block for the development of new drugs, particularly those targeting the kidney and renal system. Its nephrotoxic effects have been studied to better understand its potential applications and limitations in drug design.
Used in Research and Development:
3,5-Difluoroaniline is also utilized in research and development for the investigation of its chemical properties, reactivity, and potential applications in various fields, including material science and environmental chemistry.

Synthesis

Work on halogenated benzenes has also demonstrated the versatility of this technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5- difluoronitrobenzene giving 3,5-difluoroaniline.

InChI:InChI=1/C6H5F2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2

Upstream product

• 7664-93-9 sulfuric acid 
• 404-12-6 1,2-bis(3,5-difluorophenyl)hydrazine 
• 399-36-0 N-(2,4-difluoro-phenyl)-acetamide 
• 2265-94-3 1,3-difluoro-5-nitrobenzene 
• 1977-85-1 2,6-dichloro-3,5-difluoronitrobenzene 
• 129589-62-4 1-(tert-butoxycarbonylamino)-3,5-difluorobenzene 
• 946839-66-3 N-benzyl-3,5-difluoroaniline 
• 461-96-1 3,5-difluorobromobenzene 
• 319-88-0 1,3,5-trichlorotrifluorobenzene 
• 13527-91-8 2,4,6-trichloro-3,5-difluoro-4-iodoaniline 
• 109-86-4 2-methoxy-ethanol 
• 7803-57-8 hydrazine hydrate 
• 1634-04-4 tert-butyl methyl ether 
• 372-38-3 1,3,5-trifluorobenzene 

Downstream Products

• 99389-26-1 3,5-difluorobenzenethiol 
• 343975-35-9 N-(3,5-difluoro-phenyl)-3-methyl-4-nitro-benzamide 
• 700805-80-7 N-cyano-N'-(3,5-difluorophenyl)-O-phenylisourea 
• 212512-30-6 2'-amino-4',6'-difluoro-2-methoxyacetophenone 
• 936025-03-5 N-(3,5-difluorophenyl)-2-methyl-6-nitrobenzamide 
• 1026724-36-6 N-(3,5-difluoro-2-methoxyacetyl-phenyl)-3,4-dimethoxy-benzamide 
• 149524-31-2 4-(3-Pyridyl)-3,5-difluoroaniline 
• 149524-37-8 4-(4-Pyridyl)-3,5-difluoroaniline 
• 1026927-37-6 4-[2,6-Difluoro-4-(2,2,5,5-tetramethyl-[1,2,5]azadisilolidin-1-yl)-phenyl]-pyridine 
• 1027239-75-3 3-[2,6-Difluoro-4-(2,2,5,5-tetramethyl-[1,2,5]azadisilolidin-1-yl)-phenyl]-pyridine 
• 149524-40-3 (+/-)-5-(Iodomethyl)-3-<4-(4-pyridyl)-3,5-difluorophenyl>-2-oxazolidinone 
• 149524-34-5 (+/-)-5-(Iodomethyl)-3-<4-(3-pyridyl)-3,5-difluorophenyl>-2-oxazolidinone 
• 183124-30-3 5-Aminomethyl-3-(3,5-difluoro-4-pyridin-4-yl-phenyl)-oxazolidin-2-one 
• 149524-36-7 (+/-)-5-(Aminomethyl)-3-[4-(3-pyridyl)-3,5-difluorophenyl]-2-oxazolidinone 

Relevant articles and documents

Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air

L-(?)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95percent ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.

Preparation method of polyfluoroaniline

The invention relates to a preparation method of polyfluoroaniline, according to the method, the polyfluoroaniline is prepared by a two-step common reaction from polyfluorobenzene as a raw material, the method has the characteristics of low reaction temperature, small pressure, low cost, and the like, is suitable for industrial production application, and is convenient for large-scale production;the polyfluoroaniline product obtained by the method has less impurities and high product purity.