372117-76-5 Usage
Description
Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(methylsulfonyl)pyrimidine-5-carboxylate is a complex organic chemical compound characterized by the presence of an ethyl ester, an amino group, a sulfonyl group, and a carboxylic acid group. Its intricate structure suggests potential therapeutic applications, likely as an inhibitor or modulator of specific biological pathways. The synthesis and manipulation of this compound necessitate expertise in organic chemistry, and it is typically managed in controlled laboratory environments due to its complexity and potential biological activity.
Uses
Used in Pharmaceutical Industry:
Ethyl 4-(3-chloro-4-methoxybenzylamino)-2-(methylsulfonyl)pyrimidine-5-carboxylate serves as a crucial building block for the synthesis of a variety of drugs. Its unique functional groups and structural features make it particularly valuable in the development of medications that target specific enzymes or receptors within the body, potentially leading to more effective treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 372117-76-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,1,1 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 372117-76:
(8*3)+(7*7)+(6*2)+(5*1)+(4*1)+(3*7)+(2*7)+(1*6)=135
135 % 10 = 5
So 372117-76-5 is a valid CAS Registry Number.
372117-76-5Relevant articles and documents
Preparation method of pharmaceutical compound avanafil
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Paragraph 0014; 0043; 0050; 0053; 0054, (2019/02/10)
The invention discloses a preparation method of a pharmaceutical compound avanafil, and belongs to the technical field of synthesis of pharmaceutical compounds. The key point of the technical scheme of the invention is as follows: a synthesis route of the synthetic method of the pharmaceutical compound avanafil is shown in the specification. The synthetic method has the advantages that the yield is high, the cost is low, the method is economical and environmentally friendly and is suitable for industrialization, the product purity is high and the like, and the method is a synthetic method withindustrial production values.
The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor
Sakamoto, Toshiaki,Koga, Yuichi,Hikota, Masataka,Matsuki, Kenji,Murakami, Michino,Kikkawa, Kohei,Fujishige, Kotomi,Kotera, Jun,Omori, Kenji,Morimoto, Hiroshi,Yamada, Koichiro
, p. 5460 - 5465 (2015/01/08)
Novel pyrimidine-5-carboxamide derivatives bearing a 3-chloro-4-methoxybenzylamino group at the 4-position were identified as potent and highly selective phosphodiesterase 5 inhibitors. Among them, we successfully found 10j (avanafil) which exhibited a potent relaxant effect on isolated rabbit cavernosum (EC30 = 2.1 nM) and a high isozyme selectivity.
