372195-85-2 Usage
Description
4-Butylpiperidine hydrochloride is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by its unique chemical structure, which includes a piperidine ring with a butyl group attached to the 4-position and a hydrochloride counterion. 4-Butylpiperidine hydrochloride plays a significant role in the development of drugs targeting specific receptors and pathways in the body.
Uses
Used in Pharmaceutical Industry:
4-Butylpiperidine hydrochloride is used as a key intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of the acetylcholine orthosteric site. This application is significant because it contributes to the development of drugs that can modulate the activity of acetylcholine receptors, which are involved in various physiological processes, including memory, learning, and muscle contraction.
In the synthesis of AC 42, 4-Butylpiperidine hydrochloride serves as a building block, providing the necessary structural elements for the formation of the final drug molecule. The allosteric modulation of acetylcholine receptors by AC 42 has the potential to offer therapeutic benefits in treating cognitive disorders and other conditions related to the cholinergic system.
Furthermore, 4-Butylpiperidine hydrochloride may also be utilized in the development of other pharmaceutical compounds that target different receptors or pathways in the body. Its versatility as a synthetic intermediate makes it a valuable component in the creation of novel drugs with diverse applications in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 372195-85-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,1,9 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 372195-85:
(8*3)+(7*7)+(6*2)+(5*1)+(4*9)+(3*5)+(2*8)+(1*5)=162
162 % 10 = 2
So 372195-85-2 is a valid CAS Registry Number.
372195-85-2Relevant articles and documents
Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides
van der Heijden, Gydo,van Schaik, Timo B.,Mouarrawis, Valentinos,de Wit, Martin J. M.,Velde, Christophe M. L. Vande,Ruijter, Eelco,Orru, Romano V. A.
, p. 5313 - 5325 (2019)
An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.