37270-94-3

Basic information

• Product Name: HUMAN PF-4
• Synonyms: RECOMBINANT HUMAN PF-4;PLATELET FACTOR 4;PLATELET FACTOR-4, HUMAN;PLATELET FACTOR 4 (PF-4);PLATELET FACTOR IV, HUMAN;PF-4;PF-4, HUMAN;HUMAN PLATELET FACTOR-4
• CAS NO: 37270-94-3
• Molecular Weight: 0
• Product Categories: chemokine
• Mol File: 37270-94-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: HUMAN PF-4(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN PF-4(37270-94-3)
• EPA Substance Registry System: HUMAN PF-4(37270-94-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 37270-94-3(Hazardous Substances Data)

Usage

Description

HUMAN PF-4, also known as Platelet factor-4, is a CXC chemokine that is primarily expressed in megakaryocytes and stored in the alpha-granules of platelets. It is a 7.8kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. The gene encoding this protein is localized on human chromosome 4.

Uses

Used in Pharmaceutical Industry:
HUMAN PF-4 is used as a therapeutic agent for various medical applications due to its unique properties and functions. It plays a crucial role in wound healing, angiogenesis, and inflammation, making it a promising candidate for the development of new drugs targeting these processes.
Used in Research and Development:
HUMAN PF-4 is used as a research tool for studying the molecular mechanisms underlying platelet function, chemokine signaling, and related cellular processes. It helps researchers understand the complex interactions between platelets, leukocytes, and endothelial cells, which are essential for maintaining vascular integrity and immune response.
Used in Diagnostic Applications:
HUMAN PF-4 can be employed as a biomarker for various diseases and conditions, such as cardiovascular diseases, thrombosis, and inflammation. Its presence in blood samples can be detected and quantified, providing valuable information for the diagnosis and monitoring of these conditions.
Used in Drug Delivery Systems:
HUMAN PF-4 can be utilized in the development of targeted drug delivery systems, taking advantage of its ability to bind to specific cell surface receptors and modulate cellular processes. This can lead to the design of more effective and selective therapies with reduced side effects.

Biochem/physiol Actions

Platelet factor-4 (PF-4) is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. This protein associates with heparin and neutralizes it. It also neutralizes various negatively charged proteoglycans.