37294-05-6

Basic information

• Product Name: dimethyl (2aS,3S,4S,4aR,5S,8S,10R,10aS,10bR)-3,5,10-trihydroxy-4-[(1aR,3aS,6aS,7R,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b
• CAS NO: 37294-05-6
• Molecular Formula: C₃₃H₄₂O₁₅
• Molecular Weight: 678.6776
• Mol File: 37294-05-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 797.9°C at 760 mmHg
• Flash Point: 251.8°C
• Density: 1.54g/cm³
• Vapor Pressure: 1.93E-29mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: dimethyl (2aS,3S,4S,4aR,5S,8S,10R,10aS,10bR)-3,5,10-trihydroxy-4-[(1aR,3aS,6aS,7R,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (2aS,3S,4S,4aR,5S,8S,10R,10aS,10bR)-3,5,10-trihydroxy-4-[(1aR,3aS,6aS,7R,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b(37294-05-6)
• EPA Substance Registry System: dimethyl (2aS,3S,4S,4aR,5S,8S,10R,10aS,10bR)-3,5,10-trihydroxy-4-[(1aR,3aS,6aS,7R,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b(37294-05-6)

Safety Data

• Hazardous Substances Data: 37294-05-6(Hazardous Substances Data)

Upstream product

• 11141-17-6 azadirachtin 

Relevant articles and documents

Development of an Enzyme-Linked Immunosorbent Assay for Azadirachtins

An enzyme-linked immunosorbent assay for azadirachtin A, a bioactive tetranor-triterpenoid from the neem tree (Azadirachta indica A. Juss), was developed. The conjugates were synthesized by employing the hemisuccinate method and an ester activation method, which were previously developed. Four rabbits were immunized with either 7-hemisuccinylazadirachtin-keyhole limpet hemocyanin (KLH) or 3-hemisuccinylazadirachtin-KLH. All sera were tested against the coating antigens 7-hemisuccinylazadirachtin-bovine serum albumin (BSA) and 3-hemisuccinylazadirachtin-BSA. From this screening procedure, an assay was developed using antiserum 7056 . The assay showed an IC50 value of about 100 ppb, with a range of detection from 10 to 1000 ppb for azadirachtin A and related compounds. Thus, the method presented is a step forward in terms of inexpensive, fast, and sensitive (improvement by a factor of 100) analysis of azadirachtin and should provide a method that can easily be used more widely.

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA (PART 11) : CHARACTERISATION AND STRUCTURE ACTIVITY RELATIONSHIPS OF SOME NOVEL REARRANGED AZADIRACHTINS.

Several novel rearrangement reactions of the natural product azadirachtin and related derivatives have been characterised using a combination of x-ray crystallographic and high field nmr techniques.The insect antifeedant properties of these and a number of C7 modified compounds have been investigated.