373-28-4

Basic information

• Product Name: BRN 1697301
• Synonyms: BRN 1697301;1-fluoro-6-broMohexane
• CAS NO: 373-28-4
• Molecular Formula: C₆H₁₂BrF
• Molecular Weight: 183.0618832
• Mol File: 373-28-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 179.8 °C at 760 mmHg
• Flash Point: 64.9 °C
• Appearance: /
• Density: 1.2930
• Vapor Pressure: 1.25mmHg at 25°C
• Refractive Index: 1.4436
• CAS DataBase Reference: BRN 1697301(CAS DataBase Reference)
• NIST Chemistry Reference: BRN 1697301(373-28-4)
• EPA Substance Registry System: BRN 1697301(373-28-4)

Safety Data

• Hazardous Substances Data: 373-28-4(Hazardous Substances Data)

Usage

General Description

BRN 1697301, also known as (E)-2-Acryloylamidoethyl α-D-glucopyranoside, is a chemical compound belonging to the class of acrylamides. It is typically used as a monomer in the synthesis of polymer materials, particularly in the development of hydrogels for various biomedical applications. BRN 1697301 has also been studied for its potential as a drug delivery system and as a material for tissue engineering and regenerative medicine. Its unique molecular structure and properties make it a promising candidate for a wide range of biomedical and material science applications.

InChI:InChI=1/C6H12BrF/c7-5-3-1-2-4-6-8/h1-6H2

Upstream product

• 4286-55-9 1-bromo-6-hexanol 
• 629-03-8 1 ,6-dibromohexane 
• 373-32-0 6-fluoro-hexan-1-ol 

Downstream Products

• 408-15-1 8-fluoro-oct-1-yne 
• 1120341-48-1 (6-fluorohexyl)benzene 
• 847672-50-8 (R/S)-(4-{2-[4-(6-fluoro-hexyloxy)-phenyl]-ethyl}-2-methyl-4,5-dihydro-oxazol-4-yl)-methanol 
• 3109-58-8 16-fluorohexadecanoic acid 
• 408-09-3 6-fluoro-hexane-1-thiol 
• 353-21-9 1-Amino-7-fluoroheptane 
• 374109-22-5 (2-{2-[4-(6-fluoro-hexyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-ethoxy}-phenyl)-acetic acid methyl ester 
• 88746-44-5 1-<(2-Tetrahydropyranyl)oxy>-10-fluorodec-3-yne 
• 408-08-2 1-fluoro-6-nitro-hexane 
• 408-28-6 6-fluoro-hexylsulfanyl cyanate 
• 334-44-1 7-Fluoroheptanenitrile 

Relevant articles and documents

C-F bond substitution via aziridinium ion intermediates

Aliphatic 1,2-aminofluorides undergo extremely fast substitution reactions under the influence of lanthanum tris(hexamethyldisilazide). The substitution proceeds via an in situ generated aziridinium ion intermediate, which subsequently undergoes ring opening by addition of a nucleophile, yielding various β-substituted amines.

Benzoxazinones as PPARγ Agonists. 2. SAR of the Amide Substituent and In Vivo Results in a Type 2 Diabetes Model

A series of benzoxazinones has been synthesized and tested for PPARγ agonist activity. Synthetic approaches were developed to provide either racemic or chiral compounds. In vitro functional potency could be measured through induction of the aP2 gene, a target of PPARγ. These studies revealed that compounds with large aliphatic chains at the nitrogen of the benzoxazinone were the most potent. Substitution of the chain was tolerated and in many cases enhanced the in vitro potency of the compound. Select compounds were further tested for metabolic stability, oral bioavailability in rats, and efficacy in db/db mice after 11 days of dosing. In vivo analysis with 13 and 57 demonstrated that the series has potential for the treatment of type 2 diabetes.

Biologically active 4H-benzo [1,4]oxazin-3-ones

The invention is directed to 4h-benzo[1,4]oxazin-3-ones useful as peroxisome proliferator activated receptor gamma (PPARγ) agonists or antagonists. Pharmaceutical compositions comprising compounds of the present invention and methods of treating conditions such as NIDDM and obesity are also disclosed.