37321-09-8 Usage
Description
Apramycin, an aminoglycoside antibiotic, is a 2-deoxystreptamine derivative with a unique substitution pattern. It is characterized by its ability to inhibit bacterial protein synthesis and is known for its effectiveness against a range of bacterial infections. Apramycin is a crystalline compound that is soluble in water and slightly soluble in lower alcohols.
Uses
Used in Pharmaceutical Industry:
Apramycin is used as an antibiotic for the treatment of bacterial infections. It works by binding to the 30S ribosomal subunit in bacteria, leading to misreading of the genetic code and subsequent inhibition of protein synthesis.
Used in Veterinary Medicine:
In the veterinary field, Apramycin is used as an antibiotic to treat and prevent bacterial infections in animals, ensuring their overall health and well-being.
Used in Nephrology:
Apramycin is used in the treatment and prevention of nephrotoxin-induced kidney injuries. Its protective effects on the kidneys make it a valuable asset in the management of kidney-related conditions.
Chemical Properties:
Apramycin is characterized by its crystalline structure and high solubility in water, with slight solubility in lower alcohols. These properties contribute to its effectiveness as an antibiotic and its ease of administration in various forms.
Safety Profile
When heated to decomposition itemits acrid smoke and irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 37321-09-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,3,2 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 37321-09:
(7*3)+(6*7)+(5*3)+(4*2)+(3*1)+(2*0)+(1*9)=98
98 % 10 = 8
So 37321-09-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H41N5O11/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31/h5-21,26-32H,2-4,22-25H2,1H3
37321-09-8Relevant articles and documents
NOVEL AMINOGLYCOSIDE ANTIBIOTIC EFFECTIVE AGAINST MULTIDRUG-RESISTANT BACTERIA
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Paragraph 0299; 0306; 0331; 0335, (2018/06/15)
A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.
Total synthesis of aminoglycoside antibiotics, apramycin and saccharocin (KA 5685)
Tatsuta,Akimoto,Takahashi,et al.
, p. 529 - 538 (2007/10/02)
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