3735-45-3 Usage
Originator
Monzal ,Boenhringer Ingelheim
Manufacturing Process
1.5 mole magnesium and 1 mole 3-phenylpropyl bromide were used for
preparing of ester solution of Grignar reagent. 1 mole (3,4-
dimethoxyphenyl)dimethylaminoacetonitrile in absolute ester was added to
above reagent dropwise. Then the mixture was heated for 3 hours to reflux.
On cooling it was poured into ice with 12% hydrochloric acid. The ester layer
was separated. The water layer was alkalized with concentrate ammonia and
ammonium chloride. The precipitated oil was dissolved in ester, dried over
sodium sulfate and distilled in vacuum after removing of ester to give α-(3,4-
dimethoxyphenyl)-N,N-dimethylbenzenebutanamine (vertabutine); BP: 166°-
168°C/0.1 mm Hg. Yield 85%. The free base may be turn into colorless
hydrochloride by adding of equivalent of hydrochloric acid in ester; MP: 146°-
148°C.
Therapeutic Function
Uterine relaxant
Check Digit Verification of cas no
The CAS Registry Mumber 3735-45-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,3 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3735-45:
(6*3)+(5*7)+(4*3)+(3*5)+(2*4)+(1*5)=93
93 % 10 = 3
So 3735-45-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H27NO2/c1-21(2)18(12-8-11-16-9-6-5-7-10-16)17-13-14-19(22-3)20(15-17)23-4/h5-7,9-10,13-15,18H,8,11-12H2,1-4H3
