373623-07-5Relevant articles and documents
Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists
Akritopoulou-Zanze, Irini,Patel, Jyoti R.,Hartandi, Kresna,Brenneman, Jehrod,Winn, Martin,Pratt, John K.,Grynfarb, Marlene,Goos-Nisson, Annika,Von Geldern, Thomas W.,Kym, Philip R.
, p. 2079 - 2082 (2007/10/03)
We report the discovery of a novel class of glucocorticoid receptor (GR) antagonists based on the chromene molecular scaffold. The compounds exhibit good functional potency and an improved receptor selectivity profile for GR over other steroid receptors when compared to the classical steroidal GR-antagonist, RU-486.
GLUCOCORTICOID RECEPTOR ANTAGONISTS FOR TREATMENT OF DIABETES
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, (2008/06/13)
are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.