37394-93-7

Basic information

• Product Name: 2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE
• Synonyms: ART-CHEM-BB B015629;CHEMBRDG-BB 3015629;AKOS BBS-00004053;AKOS B015629;2-CHLORO-N-O-TOLYL-ACETAMIDE;2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE;2-chloro-N-(2-methylphenyl)acetamide(SALTDATA: FREE);2-CHLORO-ORTHO-ACETOTOLUIDIDE
• CAS NO: 37394-93-7
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• Mol File: 37394-93-7.mol
• Article Data: 91

Chemical Properties

• Boiling Point: 326°Cat760mmHg
• Flash Point: 151°C
• Appearance: /
• Density: 1.222g/cm³
• Vapor Pressure: 0.000222mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE(37394-93-7)
• EPA Substance Registry System: 2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE(37394-93-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 37394-93-7(Hazardous Substances Data)

Usage

General Description

2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE, also known as 2-chloro-N-(o-tolyl)acetamide, is a chemical compound with the molecular formula C9H10ClNO. It is a white to off-white crystalline solid that is used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds. Its structure consists of a chloro group and an N-(2-methylphenyl)acetamide group, making it a chloroacetamide derivative. It is primarily used as an intermediate in the production of drugs and pharmaceuticals, and is also used as a reagent in organic synthesis. This chemical compound has potential biological activity and may have therapeutic applications. However, it is important to handle this compound with caution and follow proper safety protocols when working with it.

InChI:InChI=1/C9H10ClNO/c1-7-4-2-3-5-8(7)11-9(12)6-10/h2-5H,6H2,1H3,(H,11,12)

Upstream product

• 95-53-4 o-toluidine 
• 79-04-9 chloroacetyl chloride 
• 100-46-9 benzylamine 
• 105-39-5 chloroacetic acid ethyl ester 
• 82185-43-1 N-(trimethylsilyl)-o-toluidine 
• 541-88-8 Chloroacetic anhydride 
• 94-69-9 2'-methylformanilide 
• 102879-43-6 2-hydroxy-N-(o-tolyl)acetamide 

Downstream Products

• 13993-02-7 piperidino-acetic acid o-toluidide 
• 62513-04-6 1-(o-tolylcarbamoyl-methyl)-pyridinium; chloride 
• 100861-58-3 N-pentyl-glycine o-toluidide 
• 38630-92-1 2-tert-Butylamino-N-o-tolyl-acetamide 
• 60093-20-1 (4-oxo-3-o-tolyl-thiazolidin-2-ylidene)-cyanamide 
• 128890-24-4 2-(2,2-Dimethyl-4-oxo-chroman-7-yloxy)-N-o-tolyl-acetamide 
• 55852-31-8 1-methyl-1-(o-tolylcarbamoyl-methyl)-piperidinium; iodide 
• 705970-78-1 2-(1-(naphthalen-1-yl)-1H-imidazol-2-ylthio)-N-o-tolylacetamide 
• 1187945-88-5 2-(1-(4-chlorophenyl)-1H-imidazol-2-ylthio)-N-o-tolylacetamide 
• 1236306-29-8 N-(2-methylphenyl)-2-(4-(4-(pyridin-4-ylmethyl)phthalazin-1-yl)piperazin-1-yl)acetamide 
• 1236306-45-8 N-(2-methylphenyl)-2-(4-(4-benzylphthalazin-1-yl)piperazin-1-yl)acetamide 
• 1134193-42-2 4-o-tolyl-2H-1,4-benzoxazin-3(4H)-one 
• 1378478-66-0 N-(2-methylphenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamide 

Relevant articles and documents

Synthesis and Anti-Arrhythmic Activity of the Chloride and Salicylate Salts of Morpholinoacetic Acid Ortho-Toluidide

Acylation of ortho-toluidine hydrochloride by chloroacetylchloride followed by amination by morpholine in the presence of an excess of Et3N produced morpholinoacetic acid ortho-toluidide and its salicylate salt. The acute toxicity and anti-arrh

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB fromPseudomonas aeruginosa

Increasing antimicrobial resistance is evolving to be one of the major threats to public health. To reduce the selection pressure and thus to avoid a fast development of resistance, novel approaches aim to target bacterial virulence instead of growth. Another strategy is to restore the activity of antibiotics already in clinical use. This can be achieved by the inhibition of resistance factors such as metallo-β-lactamases (MBLs). Since MBLs can cleave almost all β-lactam antibiotics, including the “last resort” carbapenems, their inhibition is of utmost importance. Here, we report on the synthesis andin vitroevaluation ofN-aryl mercaptoacetamides as inhibitors of both clinically relevant MBLs and the virulence factor LasB fromPseudomonas aeruginosa. All testedN-aryl mercaptoacetamides showed low micromolar to submicromolar activities on the tested enzymes IMP-7, NDM-1 and VIM-1. The two most promising compounds were further examined in NDM-1 expressingKlebsiella pneumoniaeisolates, where they restored the full activity of imipenem. Together with their LasB-inhibitory activity in the micromolar range, this class of compounds can now serve as a starting point for a multi-target inhibitor approach against both bacterial resistance and virulence, which is unprecedented in antibacterial drug discovery.

Synthesis of (2-chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides

(2-Chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides were synthesized from hydrazones obtained via the reaction of 3-formyl-2-chloroquinoline with oxamic acid thiohydrazides.