374073-85-5Relevant articles and documents
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)
Heerding, Dirk A.,Chan, George,DeWolf Jr., Walter E.,Fosberry, Andrew P.,Janson, Cheryl A.,Jaworski, Deborah D.,McManus, Edward,Miller, William H.,Moore, Terrance D.,Payne, David J.,Qiu, Xiayang,Rittenhouse, Stephen F.,Slater-Radosti, Courtney,Smith, Ward,Takata, Dennis T.,Vaidya, Kalindi S.,Yuan, Catherine C.K.,Huffman, William F.
, p. 2061 - 2065 (2001)
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
