37413-99-3

Basic information

• Product Name: 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione
• Synonyms: 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione;9,11-Epoxy-17-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione;(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-acetyl-7-hydroxy-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one;JGIRPEXTUMTWKF-NDBOTOLBSA-N
• CAS NO: 37413-99-3
• Molecular Formula: C₂₂H₂₈O₄
• Molecular Weight: 356.46
• Mol File: 37413-99-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione(37413-99-3)
• EPA Substance Registry System: 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione(37413-99-3)

Safety Data

• Hazardous Substances Data: 37413-99-3(Hazardous Substances Data)

Usage

Description

9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione, also known as E589175, is a chemical compound derived from the metabolite of momestasone furoate (M490000). It is a steroidal molecule with a unique structure that features an epoxy group at the 9,11 positions, a methyl group at the 16 position, and a 1,4-diene system. 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione plays a crucial role in the synthesis of other steroidal drugs, particularly in the preparation of 9β,11β-Epoxy-21dehydroxy betamethasone.

Uses

Used in Pharmaceutical Industry:
9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione is used as an intermediate in the synthesis of steroidal drugs, specifically for the production of 9β,11β-Epoxy-21dehydroxy betamethasone. 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione serves as a key precursor in the chemical reactions that lead to the formation of the final drug product, which has potential therapeutic applications.
In the pharmaceutical industry, 9,11-Epoxy-16-methylpregna-1,4-dien-17-ol-3,20-dione is utilized for its ability to undergo specific chemical transformations, allowing the synthesis of new and effective medications. Its unique structure and reactivity make it a valuable component in the development of steroidal drugs with potential therapeutic benefits.

Upstream product

• 14135-32-1 16β-methyl-17α-hydroxy-pregna-1,4,9(11)-triene-3,20-dione 
• 21650-83-9 20-oxo-5α-pregna-9(11),16-dien-3β-yl acetate 
• 915-35-5 hecogenin acetate 
• 467-55-0 hecogenin 
• 989-73-1 Δ⁹⁽¹¹⁾22-isoallospirosten-3β-ol-12-one-3-acetate 
• 113926-56-0 3β-acetoxy-16α,17α-epoxy-5α-pregn-9(11)-en-20-one 
• 1106-20-3 Δ⁹⁽¹¹⁾22-isoallospirosten-3β-ol 
• 884488-48-6 3β-acetoxy-16α,17α-epoxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene 
• 884488-49-7 16β-methyl-3β,17α-dihydroxy-20,20-ethylenedioxy-5α-pregn-9(11)-ene 
• 884488-47-5 16α,17α-epoxy-3β-hydroxy-5α-pregn-9(11)-en-20-one 

Downstream Products

• 987-24-6 betamethasone 21-acetate 
• 378-44-9 betamethasone 
• 37414-01-0 (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2,2-Diiodo-acetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one 
• 1879-77-2 16β-methyl-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione 

Relevant articles and documents

Synthesis of betamethasone from the waste of Thai Agave sisalana

Synthesis of betamethasone from waste of Thai A. sisalana is described. Copyright Taylor & Francis Group, LLC.