374562-42-2

Basic information

• Product Name: 2-amino-6-(1-hydroxyethyl)-benzoic acid (sodium salt)
• Synonyms: 2-amino-6-(1-hydroxyethyl)-benzoic acid (sodium salt)
• CAS NO: 374562-42-2
• Molecular Weight: 203.173
• Mol File: 374562-42-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-amino-6-(1-hydroxyethyl)-benzoic acid (sodium salt)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-(1-hydroxyethyl)-benzoic acid (sodium salt)(374562-42-2)
• EPA Substance Registry System: 2-amino-6-(1-hydroxyethyl)-benzoic acid (sodium salt)(374562-42-2)

Safety Data

• Hazardous Substances Data: 374562-42-2(Hazardous Substances Data)

Upstream product

• 13619-70-0 2-acetyl-6-nitrobenzoic acid 
• 374562-48-8 2-nitro-6-(1-hydroxyethyl)-benzoic acid (sodium salt) 

Relevant articles and documents

Concise Process for Pyriftalid Synthesis by Introducing the Mercapto Group Directly from a Nitro Group

A concise and efficient process for the synthesis of pyriftalid is described herein. The improved process features the direct introduction of the mercapto group by one-step substitution of a nitro group using sodium sulfide and elemental sulfur. A systematic study of the key step is also carried out in this article. Compared with previous routes, the optimized route is shorter and avoids a hazardous catalytic reduction and a subsequent diazotization reaction. Salt waste generated in workup is reduced as well. Pyriftalid is obtained in 68% overall yield and 99.88% purity in five steps with 3-nitrophthalic acid as the starting material.