374705-41-6

Basic information

• Product Name: 5,6,7-trihydroxy-8-methylflavone
• Synonyms: 5,6,7-trihydroxy-8-methylflavone
• CAS NO: 374705-41-6
• Molecular Weight: 284.268
• Mol File: 374705-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,6,7-trihydroxy-8-methylflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7-trihydroxy-8-methylflavone(374705-41-6)
• EPA Substance Registry System: 5,6,7-trihydroxy-8-methylflavone(374705-41-6)

Safety Data

• Hazardous Substances Data: 374705-41-6(Hazardous Substances Data)

Upstream product

• 59677-74-6 unonal 
• 109309-41-3 5-hydroxy-7,8-dimethoxy-6-methyl-2-phenyl-chromen-4-one 
• 55969-56-7 5,7-dihydroxy-8-methyl-2-phenylchromen-4-one 
• 740-33-0 mosloflavone 
• 791838-62-5 8-formyl-5,6,7-trihydroxyflavone 
• 10034-85-2 hydrogen iodide 
• 108-24-7 acetic anhydride 

Downstream Products

• 102706-32-1 5,6,7-triacetoxy-8-methyl-2-phenyl-chromen-4-one 
• 109309-40-2 5-hydroxy-6,7-dimethoxy-8-methyl-2-phenyl-chromen-4-one 
• 109688-36-0 5,6,7-trimethoxy-8-methyl-2-phenyl-chromen-4-one 

Relevant articles and documents

Structure-activity relationships for α-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: The effect of A-ring substitution

In order to estimate the effects of the A-ring hydroxyl group of baicalein (5,6,7-trihydroxyflavone, 1) on rat intestinal α-glucosidase inhibition, flavone, monohydroxyflavones, dihydroxyflavones, and methylated derivatives of 5,6,7-trihydroxyflavone were used for the structure-activity relationship (SAR) study. The importance of the 6-hydroxyl group of baicalein was validated for an exertion of the activity. And also, the tested flavones which lacked a hydroxyl substituent on any of positions 5, 6, or 7, showed no activity. Hence, the 5,6,7-trihydroxyflavone structure was concluded to be crucial for the potent inhibitory activity. In addition, an introduction of electron-withdrawing or electron-donating groups at position 8 of baicalein led to a dramatic decrease for activity, except for 8-fluoro-5,6,7-trihydroxyflavone, which carried a less bulky substituent on position 8. Hence, this result suggested that a sterically bulky substituent on C-8 of baicalein was detrimental for the activity regardless of its electronic nature. Through examining the inhibitory mechanism of baicalein against rat intestinal α-glucosidase, it was suggested to be a mixed type inhibition.