374752-64-4

Basic information

• Product Name: (2S,3R)-3-Hydroxy-2-methyl-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester
• Synonyms: (2S,3R)-3-Hydroxy-2-methyl-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester
• CAS NO: 374752-64-4
• Molecular Weight: 316.375
• Mol File: 374752-64-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,3R)-3-Hydroxy-2-methyl-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-Hydroxy-2-methyl-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester(374752-64-4)
• EPA Substance Registry System: (2S,3R)-3-Hydroxy-2-methyl-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester(374752-64-4)

Safety Data

• Hazardous Substances Data: 374752-64-4(Hazardous Substances Data)

Upstream product

• 483305-59-5 (4S,5R)-3-[(2S,3R)-3-Hydroxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 482626-31-3 (2S,3R)-3-Hydroxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanoic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 482626-32-4 (2S,3R)-3,5-Dihydroxy-2-methyl-pentanoic acid methyl ester 

Downstream Products

• 100905-89-3 pamamycin-607 
• 482626-33-5 (2S,3R)-2-Methyl-3-((E)-3-oxo-hex-1-enyloxy)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester 

Relevant articles and documents

Stereoselective synthesis of pamamycin-607

A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.