374794-68-0Relevant articles and documents
Reductive carboxylation of aromatic esters by electron transfer from magnesium metal
Maekawa, Hirofumi,Okawara, Hikaru,Murakami, Taro
supporting information, p. 206 - 209 (2016/12/28)
Magnesium-promoted reductive carboxylation of ethyl benzoate in the presence of chlorotrimethylsilane in N,N-dimethylformamide brought about a new carbon-carbon bond formation between the carbonyl carbon atom and carbon dioxide to give the corresponding benzoylformic acid in good yield. It is noteworthy that only ethyl benzoates with substituents at the meta-position were converted into benzoylformic acid derivatives. Moreover, no mandelic acid was detected even under the reductive conditions. This result indicates that benzoylformic acid was obtained after hydrolysis of a carboxylated intermediate, which would be alive as a stabilized structure in the reaction media.
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for urge urinary incontinence
Hewawasam, Piyasena,Erway, Matthew,Thalody, George,Weiner, Harvey,Boissard, Christopher G.,Gribkoff, Valentin K.,Meanwell, Nicholas A.,Lodge, Nicholas,Starrett, Jr, John E.
, p. 1117 - 1120 (2007/10/03)
A series of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones was prepared and shown by electrophysiological analysis to activate a cloned maxi-K channel mSlo (or hSlo) expressed in Xenopus laevis oocytes. The effects of these structurally novel maxi-K channel openers on bladder contractile function were studied in vitro using isolated rat bladder strips pre-contracted with carbachol. Several 1,3-diaryl 1,2,4-(4H)-triazol-5-one derivatives were found to be potent smooth muscle relaxants but this activity did not completely correlate with maxi-K channel opening.
