374794-88-4

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-hydroxy-4-(3-hydroxypropyl)-, 1,1-diMethylethyl ester
• Synonyms: 1-Piperidinecarboxylic acid, 4-hydroxy-4-(3-hydroxypropyl)-, 1,1-diMethylethyl ester;tert-butyl 4-hydroxy-4-(3-hydroxypropyl)piperidine-1-carboxylate
• CAS NO: 374794-88-4
• Molecular Formula: C₁₃H₂₅NO₄
• Molecular Weight: 259.3419
• Mol File: 374794-88-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 378.949°C at 760 mmHg
• Flash Point: 182.982°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-hydroxy-4-(3-hydroxypropyl)-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-hydroxy-4-(3-hydroxypropyl)-, 1,1-diMethylethyl ester(374794-88-4)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-hydroxy-4-(3-hydroxypropyl)-, 1,1-diMethylethyl ester(374794-88-4)

Safety Data

• Hazardous Substances Data: 374794-88-4(Hazardous Substances Data)

Usage

Structure

An ester derivative of 4-hydroxy-4-(3-hydroxypropyl)piperidine-1-carboxylic acid

Usage

Commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical products, and has potential therapeutic applications.

Safety precautions

Hazards may be associated with the handling and use of this compound, so it is important to follow proper safety precautions and guidelines.

InChI:InChI=1/C13H25NO4/c1-12(2,3)18-11(16)14-8-6-13(17,7-9-14)5-4-10-15/h15,17H,4-10H2,1-3H3

Upstream product

• 203662-51-5 1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine 
• 1192122-44-3 tert-butyl 4-[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]-4-hydroxypiperidine-1-carboxylate 
• 374794-87-3 1,1-dimethylethyl 4-hydroxy-4-(3-hydroxypropynyl)-1-piperidinecarboxylate 
• 374794-91-9 1,1-dimethylethyl 4-(3-ethoxy-3-oxoprop-1-yl)-4-hydroxy-1-piperidinecarboxylate 
• 374794-90-8 1,1-dimethylethyl 4-(3-ethoxy-3-oxo-1-propynyl)-4-hydroxy-1-piperidinecarboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 301226-27-7 tert-butyl 2-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 

Downstream Products

• 884586-68-9 4-(3-hydroxypropyl)piperidin-4-ol 
• 896103-70-1 2-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 176-92-1 4-dioxa-8-azaspiro[4.5]decane 
• 374794-89-5 1,1-dimethylethyl 1-oxa-8-azaspiro[4,5]decane-8-carboxylate 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula (I) and compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS

The present invention relates to the compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and W are as defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.