374794-96-4

Basic information

• Product Name: 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate;tert-butyl 2-oxa-8-azaspiro[4.5]decane-8-carboxylate;2-Oxa-8-azaspiro[4.5]decane-8-carboxylicacid;2-Oxa-8-azaspiro[4.5]decane-8-CARBOXYLIC ACID TERT-BUTYL ESTER;2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 374794-96-4
• Molecular Formula: C₁₃H₂₃NO₃
• Molecular Weight: 241.33
• Product Categories: API intermediates
• Mol File: 374794-96-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 333.508°C at 760 mmHg
• Flash Point: 155.501°C
• Appearance: /
• Density: 1.084g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: 2-8°C
• PKA: -0.77±0.20(Predicted)
• CAS DataBase Reference: 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate(374794-96-4)
• EPA Substance Registry System: 1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate(374794-96-4)

Safety Data

• Hazardous Substances Data: 374794-96-4(Hazardous Substances Data)

Usage

General Description

1,1-Dimethylethyl 2-Oxa-8-azaspiro[4.5]decane-8-carboxylate is a chemical compound with a complex and specific structure. It belongs to the class of organic compounds known as spirocompounds, which are characterized by a unique carbon framework. This particular compound is a carboxylate ester, meaning it contains a carbonyl group attached to an oxygen atom, and it has a tert-butyl group and an oxane ring as part of its structure. Its chemical properties and potential uses are not readily available, but it may have applications in the pharmaceutical or chemical industries due to its unique structure and potential reactivity.

InChI:InChI=1/C13H23NO3/c1-12(2,3)17-11(15)14-7-4-13(5-8-14)6-9-16-10-13/h4-10H2,1-3H3

Upstream product

• 247133-32-0 4-ethoxycarbonyl-4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 
• 146603-99-8 1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate 
• 154348-08-0 1,1-dimethylethyl 1-oxo-2-oxa-8-azaspiro[4,5]decane-8-carboxylate 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 236406-38-5 1,1-dimethylethyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)-1-piperidinecarboxylate 

Downstream Products

• 374791-95-4 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide 
• 374791-95-4 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-propionamide 
• 176-69-2 2-oxa-8-azaspiro[4.5]decane 

Relevant articles and documents

Cyclohexyl derivatives and their use as therapeutic agents

The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II

A series of novel 4,4-disubstituted cyclohexylamines as NK1 receptor antagonists is described: modifications to the amine moiety retain NK1 receptor binding affinity whilst disrupting IKr affinity.