37493-16-6

Basic information

• Product Name: (S)-1-Chloro-2-propanol
• Synonyms: (S)-1-CHLORO-2-PROPANOL;2-PROPANOL, 1-CHLORO-, (2S)-;(S) -1-CHLORO-2-PROPANOL 98+%;(S)-1-Chloro-2-propa;(2S)-1-chloropropan-2-ol
• CAS NO: 37493-16-6
• Molecular Formula: C₃H₇ClO
• Molecular Weight: 94.54
• Product Categories: Chiral Compound
• Mol File: 37493-16-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-1-Chloro-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-Chloro-2-propanol(37493-16-6)
• EPA Substance Registry System: (S)-1-Chloro-2-propanol(37493-16-6)

Safety Data

• Hazardous Substances Data: 37493-16-6(Hazardous Substances Data)

Usage

General Description

(S)-1-Chloro-2-propanol, also known as chlorohydrin, is a halogenated alcohol compound with the chemical formula C3H7ClO. It is a colorless liquid with a pungent odor, and it is commonly used as a chemical intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the synthesis of surfactants and as a solvent in chemical reactions. (S)-1-Chloro-2-propanol is considered hazardous, as prolonged or repeated exposure can cause irritation to the skin, eyes, and respiratory system. It is important to handle this chemical with care and follow proper safety protocols when working with it.

Upstream product

• 187737-37-7 propene 
• 36220-92-5 1-chloro-2-benzoyloxypropane 
• 78-95-5 chloroacetone 
• 108-05-4 vinyl acetate 
• 127-00-4 1-Chloro-2-propanol 
• 75-56-9 methyloxirane 

Downstream Products

• 16088-62-3 (S)-Propylene oxide 
• 141339-84-6 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-chloro-1-methyl-ethyl ester 

Relevant articles and documents

Empirical method for predicting enantioselectivity in catalytic reactions: demonstration with lipase and oxazaborolidine

We derived a novel equation capable of predicting the degree of enantioselectivity in a catalytic reaction without any knowledge of the reaction mechanism and/or the transition-state structure, and tested the validity of this equation by changing substrates systematically in the lipase or oxazaborolidine-catalyzed reactions. A good correlation was observed between the predicted and observed E values, and the stereochemistry of the products could be predicted correctly in most cases (28 out of 30).

Highly reactive and enantioselective kinetic resolution of terminal epoxides with H2O and HCl catalyzed by new chiral (salen)Co complex linked with Al

The asymmetric hydrolytic kinetic resolution (HKR) of racemic terminal epoxides by new easily synthesized dimeric chiral (salen)Co bearing Al, provides a practical and straightforward method for the synthesis of enantiomerically enriched terminal epoxides (>99% ee) and diols. An inorganic acid, HCl is applied first time for the asymmetric ring opening reaction of terminal epoxides. Reactions are conveniently carried out at room temperature under an air atmosphere.

Oxidation of olefins by palladium(II): Part 17. An asymmetric chlorohydrin synthesis catalyzed by a bimetallic palladium(II) complex

Previous studies showed that oxidation of α-olefins with monometallic catalysts containing chiral diphosphines and diamines gave chlorohydrins with poor to good enantioselectivites (28-82% ee). The present studies demonstrate that bimetallic catalysts containing a β-triketone and bridging chiral diphosphine and diamines are excellent catalysts for this reaction giving enantioselectivites considerably higher than the monometallic catalysts. Enantioselectivities were more than 50% for most olefins tested. The highest optical purities were 94% ee for propene and 93% ee for allylphenyl ether. A useful feature of this asymmetric synthesis is the fact it is a net air oxidation.