37538-67-3

Basic information

• Product Name: Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI)
• Synonyms: Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI);3H-Pyrido[3,2-d]pyrimidin-4-one;Pyrido[3,2-d]pyrimidin-4(3H)-one;Pyrido[3,2-d]pyrimidin-4-ol;3H,4H-pyrido[3,2-d]pyrimidin-4-one;Pyrido[3,2-d]pyrimidin-4(1H)-one
• CAS NO: 37538-67-3
• Molecular Formula: C₇H₅N₃O
• Molecular Weight: 147.1341
• Product Categories: PYRIMIDINE
• Mol File: 37538-67-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: >300℃
• Boiling Point: 346℃
• Flash Point: 163℃
• Appearance: /
• Density: 1.47
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI)(37538-67-3)
• EPA Substance Registry System: Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI)(37538-67-3)

Safety Data

• Hazardous Substances Data: 37538-67-3(Hazardous Substances Data)

Usage

General Description

Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI) is a chemical compound with the molecular formula C8H5N3O. It is a heterocyclic compound with a pyrido-pyrimidine structure, containing a pyridine ring fused to a pyrimidine ring. Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI) has potential biological activity and is being studied for its pharmacological properties. It is also used as a building block in the synthesis of pharmaceuticals and other organic compounds. Its structure and properties make it a versatile and important compound in the field of medicinal chemistry and drug development.

Upstream product

• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 77287-34-4 formamide 
• 875233-01-5 pyrido[3,2-d]pyrimidin-4-amine 
• 50608-99-6 3-amino-pyridine-2-carboxylic acid amide 
• 122-51-0 orthoformic acid triethyl ester 
• 93683-65-9 6-chloro-3-nitropicolinonitrile 
• 171178-21-5 6-chloro-3-nitropyridine-2-carboxamide 
• 463-52-5 formamidine 
• 175358-01-7 3-amino-6-chloro-pyridine-2-carboxylic acid amide 
• 873398-21-1 1H-pyrido[3,2-d]pyrimidine-2,4-dithione 
• 37538-68-4 pyrido<3,2-d>pyrimidine-2,4(1H,3H)-dione 
• 873398-20-0 4-amino-1H-pyrido[3,2-d]pyrimidine-2-thione 
• 39551-54-7 2,4-dichloropyrido[3,2-d]-pyrimidine 

Downstream Products

• 884484-88-2 3-benzyloxy-2-[2-hydroxy-3-(4-oxo-4H-pyrido[3,2-d]pyrimidin-3-yl)-propyl]-piperidine-1-carboxylic acid benzyl ester 
• 51674-77-2 4-chloropyrido<3,2-d>pyrimidine 
• 175358-02-8 4,6-dichloropyrido<3,2-d>pyrimidine 
• 1420618-39-8 C₂₄H₁₈ClN₅O 
• 1420619-03-9 C₂₉H₂₃N₇O 
• 1420618-60-5 C₂₈H₂₃N₇O 
• 1312757-56-4 C₂₉H₃₀N₄O₅ 

Relevant articles and documents

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Design, synthesis and bioactivity evaluation of 4,6-disubstituted pyrido[3,2-d]pyrimidine derivatives as mnk and HDAC inhibitors

Both HDACs and Mnks play important role in translating multiple oncogenic signaling pathways during oncogenesis. As HDAC and Mnk are highly expressed in a variety of tumors; thus simultaneous inhibit HDAC and Mnk can increase the inhibition of tumor cell proliferation and provide a new way of inhibiting tumor growth. Based on the previous work and the merge pharmacophore method; we designed and synthesized a series of 4,6-disubstituted pyrido[3,2-d]pyrimidine derivatives as HDAC and Mnk dual inhibitors. Among them; compound A12 displayed good HDAC and Mnk inhibitory activity. In vitro antiproliferative assay; compound A12 exhibited the best antiproliferative activity against human prostate cancer PC-3 cells. Docking study revealed that the pyrido[3,2-d]pyrimidine framework and hydroxamic acid motif of compound A12 were essential for maintaining the activity of HDAC and Mnk. These result indicated that A12 was a potent Mnk /HDAC inhibitor and will be further researched.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.