37540-16-2

Basic information

• Product Name: 5-Chlor-2-hydroxy-benzoesaeure-butylester
• Synonyms: 5-Chlor-2-hydroxy-benzoesaeure-butylester
• CAS NO: 37540-16-2
• Molecular Weight: 228.675
• Mol File: 37540-16-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Chlor-2-hydroxy-benzoesaeure-butylester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chlor-2-hydroxy-benzoesaeure-butylester(37540-16-2)
• EPA Substance Registry System: 5-Chlor-2-hydroxy-benzoesaeure-butylester(37540-16-2)

Safety Data

• Hazardous Substances Data: 37540-16-2(Hazardous Substances Data)

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 71-36-3 butan-1-ol 

Downstream Products

• 7120-43-6 5-chlorosalicylamide 

Relevant articles and documents

Method of preparing salicylamides

The present invention provides a fast, high yield method for preparing salicylamide intermediates. The method comprises reacting a C4 or higher alkyl ester of salicylic acid or derivative thereof with at least one amine selected from the group consisting of monoalkylamines, dialkylamines, ammonia, and any combination of any of the foregoing in alcohol to yield the sali-cylamide. The C4 or higher alkyl ester of salicylic acid or a derivative thereof is preferably prepared by reacting salicylic acid or a derivative thereof with a C4 or higher alcohol in presence of at least one of sulfuric acid, a sulfonic acid, and a mineral acid. This process for preparing salicylamide intermediates from salicylic acid or derivative thereof generally has a cycle time of about 2 days, and yields about 95% of a 99% pure material. In comparison, when a C3 or lower alkyl ester is used in lieu of the C4 or higher alkyl ester, the process generally has a cycle time of 7-9 days and yields about 60% of a 95% pure material. Methods of preparing an alkylated salicylamide are also provided.