37552-67-3

Basic information

• Product Name: 2-Azetidinone, 1-(4-methylphenyl)-3,4-diphenyl-, trans-
• CAS NO: 37552-67-3
• Molecular Formula: C22H19NO
• Molecular Weight: 313.399
• Mol File: 37552-67-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Azetidinone, 1-(4-methylphenyl)-3,4-diphenyl-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinone, 1-(4-methylphenyl)-3,4-diphenyl-, trans-(37552-67-3)
• EPA Substance Registry System: 2-Azetidinone, 1-(4-methylphenyl)-3,4-diphenyl-, trans-(37552-67-3)

Safety Data

• Hazardous Substances Data: 37552-67-3(Hazardous Substances Data)

Upstream product

• 64450-59-5 (2RS,3SR)-2,3-diphenyl-3-p-toluidino-propionic acid 
• 98-09-9 benzenesulfonyl chloride 
• 103-80-0 phenylacetyl chloride 
• 2272-45-9 benzal-p-toluidine 
• 19064-77-8 C-phenyl-N-p-tolyl-nitrone 
• 536-74-3 phenylacetylene 
• 19064-77-8 N-benzylidene-4-methylaniline oxide 
• 103-82-2 phenylacetic acid 
• 1613-92-9 (E)-N-benzylidene-4-toluidine 
• 3282-32-4 2-diazo-acetophenone 

Relevant articles and documents

Development of TsDPEN based imine-containing ligands for the copper-catalysed asymmetric Kinugasa reaction

A novel class of chiralN,N,Nimine-containing ligands derived from TsDPEN (N-(p-tosyl)-1,2-diphenylethylene-1,2-diamine) has been developed and applied to the copper-catalyzed asymmetric Kinugasa reaction. The copper(ii) salt proved to be an efficient catalyst precursor, and it provides an efficient way to synthesize enantioenrichedcis-β-lactam. The pathway is air-tolerant and easily manipulated, and the ligands are easy to synthesize. A working model is proposed in which the stereocontrolling step is the [2 + 2] cycloaddition between ketene and imine to explain the observed stereoselectivities.

Trisoxazoline/Cu(II)-promoted Kinugasa reaction. Enantioselective synthesis of β-lactams

The reactions of nitrones with terminal alkynes, catalyzed by chiral iPr-trisoxazoline 23/Cu(ClO4)2·6H 2O under air atmosphere, afforded β-lactams in moderate to good yields with up to 85% ee. The diastereoselec

Synthesis and antimicrobial activity of 1,3,4-triaryl-2-azetidinones

A set of substituted 1,3,4-triaryl-2-azetidinones were synthesized and characterized. Their antimicrobial activity, against Gram+ and Gram- bacteria and Fungi, was tested. The compounds 23 and 30 showed remarkable activity against Pseudomonas aeruginosa.