37560-45-5

Basic information

• Product Name: 1H-Pyrrole, 1-(3,5-dimethylphenyl)-
• CAS NO: 37560-45-5
• Molecular Formula: C12H13N
• Molecular Weight: 171.242
• Mol File: 37560-45-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-(3,5-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-(3,5-dimethylphenyl)-(37560-45-5)
• EPA Substance Registry System: 1H-Pyrrole, 1-(3,5-dimethylphenyl)-(37560-45-5)

Safety Data

• Hazardous Substances Data: 37560-45-5(Hazardous Substances Data)

Usage

Aromatic heterocycle

pyrrole

Substituent

3,5-dimethylphenyl group

Attachment

to the nitrogen atom of the pyrrole ring

Use in organic synthesis

as a building block to create compounds with potential pharmacological properties

Unique structure

valuable tool in the development of new drugs and biologically active molecules

Interest in materials science

potential applications in the development of organic electronic devices.

Upstream product

• 109-97-7 pyrrole 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 108-69-0 3,5-dimethylaminoaniline 
• 25653-16-1 tris(3,5-dimethylphenyl) phosphate 
• 6117-80-2 1,4-butenediol 
• 99-12-7 5-nitro-m-xylene 
• 110-65-6 1,4-dihydroxybut-2-yne 

Relevant articles and documents

Utilization of caffeine carbon supported cobalt catalyst in the tandem synthesis of pyrroles from nitroarenes and alkenyl diols

Employing bio-waste caffeine carbon-supported heterogeneous cobalt catalyst, synthesis of various substituted pyrrole derivatives is reported. In this methodology, pyrroles were synthesized through coupling between nitroarenes and alkenyl diols in a tandem manner. Among all the heterogeneous catalysts Co(OAc)2-CC-800 displayed the highest catalytic activity. Preparative scale synthesis of pyrroles and synthesis of anti-tubercular agent 5-(4-(1H-pyrrol-1-yl)phenyl)-1,3,4-oxadiazole-2-thiol revealed the practical applicability of this protocol. Several kinetic experiments and Hammett studies were conducted to understand the probable mechanism and electronic effects on this transformation.

Palladium-catalyzed c(sp2)-n bond cross-coupling with triaryl phosphates

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(-cinnamyl)Cl]2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Efficient and recyclable copper-based MOF-catalyzed N-arylation of N-containing heterocycles with aryliodides

Copper-based MOF-199 was used as an efficient heterogeneous catalyst to catalyze cross-coupling reactions between N-containing heterocycles and aryliodides with high yields. The catalyst can be easily separated from the reaction mixture, and can be reused at least 5 times without significantly decreasing the activity. The XRD results showed that the crystallinity and structure of MOF-199 can be maintained well during the coupling reaction.