37563-42-1Relevant articles and documents
Oxalohydrazide Ligands for Copper-Catalyzed C?O Coupling Reactions with High Turnover Numbers
Ray, Ritwika,Hartwig, John F.
supporting information, p. 8203 - 8211 (2021/03/08)
Here, we report a class of ligands based on oxalohydrazide cores and N-amino pyrrole and N-amino indole units that generates long-lived copper catalysts for couplings that form the C?O bonds in biaryl ethers. These Cu-catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper-catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcohols. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcohols and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures.
Preparation method of substituted phenoxy benzylamine compound and preparation method of pyrazole carboxamide compound
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Paragraph 0028-0031, (2021/06/26)
The invention discloses a preparation method of a substituted phenoxy benzylamine compound. P-halobenzonitrile is taken as an initial raw material, R'OH is taken as a solvent in the presence of R'OM, the substituted phenoxy benzylamine compound is obtained through hydrogen reduction, and the preparation method has the advantages of high yield and high purity. The invention also discloses a preparation method of pyrazole carboxamide. The preparation method of pyrazole carboxamide comprises the following steps: salifying the substituted phenoxy benzylamine compound, and reacting with a substituted pyrazole acyl chloride compound to prepare the pyrazole carboxamide compound at an expected high yield. The preparation methods provided by the invention have the advantages of high product purity, high yield, low solvent loss and low production cost.
Novel cobalt-valine catalyzed O-arylation of phenols with electron deficient aryl iodides
Ujwaldev, Sankuviruthiyil M.,Saranya, Salim,Harry, Nissy Ann,Anilkumar, Gopinathan
, p. 339 - 346 (2019/01/18)
Abstract: A Novel cobalt-catalyzed O-arylation of phenols with electron deficient aryl iodides is described. The reaction employs cheap and easy-to-handle cobalt acetate tetrahydrate as the catalyst precursor and naturally occurring l-valine as the ligand without the use of any transmetallating or reducing agents. The new protocol offers a wide scope for a variety of phenols towards O-arylation with moderate to excellent yields with electron deficient aryl iodides.