37619-25-3

Basic information

• Product Name: 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)
• Synonyms: 1H-Benzimidazole-4-carboxylicacid,methylester(9CI);1H-Benzimidazole-4-carboxylic acid methyl ester;methyl 1H-benzo[d]imidazole-7-carboxylate;Methyl 1H-benzo[d]iMidazole-4-carboxylate;Methyl 1,3-benzodiazole-4-carboxylate;Methyl 3H-benzimidazole-4-carboxylate;Methyl 4-benzimidazolecarboxylate;methyl 4(7)-benzimidazolylcarboxylate
• CAS NO: 37619-25-3
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.18
• Product Categories: BENZIMIDAZOLE;pharmacetical
• Mol File: 37619-25-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 416.2°Cat760mmHg
• Flash Point: 205.5°C
• Appearance: /
• Density: 1.324g/cm³
• Vapor Pressure: 3.9E-07mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.78±0.30(Predicted)
• CAS DataBase Reference: 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)(37619-25-3)
• EPA Substance Registry System: 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)(37619-25-3)

Safety Data

• Hazardous Substances Data: 37619-25-3(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole-4-carboxylic acid, methyl ester (9CI) is a chemical compound with the molecular formula C10H9N3O2. It is a derivative of benzimidazole and is commonly used in pharmaceutical research and drug development. The methyl ester group makes this compound more stable and easily able to penetrate cell membranes, making it a valuable building block for potential drug candidates. This chemical has shown potential as an antitumor agent and has also been studied for its potential use in the treatment of neurodegenerative diseases. Additionally, it has been synthesized and studied for its potential to act as an antiviral and antiparasitic agent. Its versatile properties make it a valuable compound in medicinal chemistry and pharmaceutical research.

InChI:InChI=1/C9H8N2O2/c1-13-9(12)6-3-2-4-7-8(6)11-5-10-7/h2-5H,1H3,(H,10,11)

Upstream product

• 46006-36-4 benzimidazole-4-carboxylic acid 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 149-73-5 trimethyl orthoformate 
• 57113-91-4 methyl 3-nitroanthranilate 
• 603-81-6 2,3-diaminobenzoic acid 
• 606-18-8 3-nitroanthranilic acid 
• 77326-45-5 2-carbamoyl-3-nitrobenzoic acid 
• 641-70-3 3-nitrophthalic acid anhydride 
• 64-18-6 formic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 67-56-1 methanol 

Downstream Products

• 667919-16-6 1-phenyl-1H-benzoimidazole-4-carboxylic acid methyl ester 
• 132873-77-9 4-(bromomethyl)benzimidazole-1-carboxylic acid,1,1-dimethylethyl ester 
• 65658-13-1 (1H-benzo[d]imidazol-4-yl)methanol 
• 1352874-02-2 N-{4'-[3-(1H-Benzoimidazol-4-ylmethyl)-6-fluoro-2-imino-2,3-dihydro-benzoimidazol-1-yl]-5-chloro-biphenyl-2-yl}-acetamide 
• 1422206-13-0 methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate 
• 1422205-93-3 methyl 6-amino-1H-benzimidazole-4-carboxylate 
• 1422205-94-4 methyl 6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate 
• 144876-36-8 1H-benzo[d]imidazole-4-carbaldehyde 

Relevant articles and documents

Benzimidazole derivative BI308 as well as preparation method and application thereof

The invention discloses a benzimidazole derivative BI308 and a preparation method thereof, and the benzimidazole derivative BI308 is chemically named as methyl 1-[(2R, 3R, 4S, 5R)-3, 4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H benzo [d] imidazole-4-carboxylic ester. The benzimidazole derivative and the pharmaceutically acceptable salt, the solvate and the hydrate of the benzimidazole derivative have excellent in-vivo and in-vitro anti-tumor activity on MCF-7, SK-BR-3, HCT 116, U-118 MG, U-87 MG and MDA-MB-468, and have a relatively good application prospect in preparation of anti-tumor drugs.

Benzimidazole derivative BI361 and preparation method and application thereof

The invention discloses a benzimidazole derivative BI361 and a preparation method thereof. The chemical name of the benzimidazole derivative BI361 is {1-[tetrahydro-3, 4-dihydroxy-5-(hydroxymethyl) furan-2-yl]-1H-benzo [d] imidazol-4-yl} (piperidin-1-yl) ketone. The benzimidazole derivative and pharmaceutically acceptable salts, solvates and hydrates thereof have excellent anti-tumor in-vivo and in-vitro activity on MCF-7, SK-BR-3, HCT 116, U-118 MG, U-87 MG and MDA-MB-468, and have good application prospects in preparation of anti-tumor drugs.

BENZIMIDAZOLES DERIVATIVES AS ANTI-TUBERCULOSIS AGENTS

The present invention provides novel compounds of benzimidazole derivatives as anti-tubercular agents and their pharmaceutically acceptable salts for use as bactericidal therapeutics. The invention also provides a pharmaceutical composition comprising a c