376348-76-4

Basic information

• Product Name: ETHYL (3S)-3-(4,4-DIFLUOROCYCLOHEXANE-1-CARBOXAMIDO)-3-PHENYLPROPANOATE
• Synonyms: ETHYL (3S)-3-(4,4-DIFLUOROCYCLOHEXANE-1-CARBOXAMIDO)-3-PHENYLPROPANOATE;Ethyl (3S)-3-[(4,4-difluorocyclohexanecarbonyl)amino]-3-phenylpropanoate
• CAS NO: 376348-76-4
• Molecular Formula: C18H23F2NO3
• Molecular Weight: 339.3769264
• Mol File: 376348-76-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL (3S)-3-(4,4-DIFLUOROCYCLOHEXANE-1-CARBOXAMIDO)-3-PHENYLPROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL (3S)-3-(4,4-DIFLUOROCYCLOHEXANE-1-CARBOXAMIDO)-3-PHENYLPROPANOATE(376348-76-4)
• EPA Substance Registry System: ETHYL (3S)-3-(4,4-DIFLUOROCYCLOHEXANE-1-CARBOXAMIDO)-3-PHENYLPROPANOATE(376348-76-4)

Safety Data

• Hazardous Substances Data: 376348-76-4(Hazardous Substances Data)

Upstream product

• 376348-75-3 4,4-difluorocyclohexane-1-carbonyl chloride 
• 340188-50-3 ethyl (S)-3-amino-3-phenyl-propionate hydrochloride 

Downstream Products

• 376348-65-1 maraviroc 
• 376348-77-5 (S)-4,4-difluoro-N-(3-hydroxy-1-phenylpropyl)cyclohexanecarboxamide 
• 376348-78-6 4,4-difluorocyclohexanecarboxylic acid (3-oxo-1-phenyl-propyl)-amide 

Relevant articles and documents

Process research and scale-up of a commercialisable route to maraviroc (UK-427,857), a CCR-5 receptor antagonist

A six-step synthetic route to the CCR-5 receptor antagonist, Maraviroc (UK-427,857) (1) has been developed and demonstrated at scale in a pilot plant. The route has supported four Pilot-Plant campaigns and has produced multikilogram quantities of 1. Continued development of the synthetic route has resulted in a robust process with improved throughput compared to that of the original synthesis (Haycock-Lewandowski, S. J.; Mawby, N. J.; Wilder, A.; Ahman, J. Org. Process Res. Dev. 2008, 12, 1094-1103).