376591-05-8

Basic information

• Product Name: (3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE
• Synonyms: (R)-1-Benzyl-3-(ethylamino)pyrrolidine;(3R)-(-)-1-Benzyl-3-(ethylamino)pyrrolidine;(3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE;(3R)-(-)-Benzyl-3-(ethylamino)pyrrolidine
• CAS NO: 376591-05-8
• Molecular Formula: C13H20N2
• Molecular Weight: 204.31
• Product Categories: Chiral Building Blocks;Synthetic Organic Chemistry;3-Aminopyrrolidines;Amines (Chiral);Chiral 3-Aminopyrrolidines
• Mol File: 376591-05-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 290.5°C at 760 mmHg
• Flash Point: 108.7°C
• Appearance: /
• Density: 0.98
• Vapor Pressure: 0.00206mmHg at 25°C
• Refractive Index: -8 ° (C=10, EtOH)
• CAS DataBase Reference: (3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE(376591-05-8)
• EPA Substance Registry System: (3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE(376591-05-8)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 376591-05-8(Hazardous Substances Data)

Usage

General Description

(3R)-(-)-1-Benzyl-3-(ethylamino)pyrrolidine is a chemical compound with a unique molecular structure consisting of a pyrrolidine ring, a benzyl group, and an ethylamino group. It is a chiral compound with a specific stereochemistry denoted by the (3R)-(-) prefix. (3R)-(-)-1-Benzyl-3-(ethylamino)pyrrolidine has potential applications in organic synthesis, pharmaceuticals, and research, as it possesses interesting properties and molecular interactions that make it valuable for various scientific and industrial purposes. Additionally, it may have biological activities and serve as a building block for the synthesis of more complex molecules. Overall, (3R)-(-)-1-Benzyl-3-(ethylamino)pyrrolidine is a versatile and intriguing chemical compound with a range of potential uses and implications in the field of chemistry.

InChI:InChI=1/C13H20N2/c1-2-14-13-8-9-15(11-13)10-12-6-4-3-5-7-12/h3-7,13-14H,2,8-11H2,1H3/t13-/m1/s1

Upstream product

• 114715-39-8 (R)-1-benzyl-3-aminopyrrolidine 
• 114636-33-8 (R)-N-(1-benzylpyrrolidine-3-yl)acetamide 

Downstream Products

• 381670-30-0 (R)-3-ethylaminopyrrolidine 

Relevant articles and documents

Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

A series of 3(R)-aminopyrrolidine derivatives were designed and synthesized for JAK1-selective inhibitors through the modification of tofacitinib's core structure, (3R,4R)-3-amino-4-methylpiperidine. From the new core structures, we selected (R)-N-methyl-N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a scaffold for further SAR studies. From biochemical enzyme assays and liver microsomal stability tests, (R)-3-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile (6) was chosen for further in vivo test through oral administration. Compound 6 showed improved selectivity for JAK1 compared to that of tofacitinib (IC50 11, 2.4 × 102, 2.8 × 103, and 1.1 × 102 nM for JAK1, JAK2, JAK3, and TYK2, respectively). In CIA and AIA model tests, compound 6 exhibited similar efficacy to tofacitinib citrate.

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.