376646-62-7

Basic information

• Product Name: 4-BROMO-2-METHYLBENZYLAMINE
• Synonyms: 4-BROMO-2-METHYLBENZYLAMINE;RARECHEM AL BW 0436;(4-BroMo-2-Methylphenyl)MethanaMine;1-(4-bromo-2-methylphenyl)methanamine;4-Bromo-2-methylbenzenemethanamine;(4-Bromo-2-methylphenyl);Benzenemethanamine, 4-bromo-2-methyl-
• CAS NO: 376646-62-7
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 376646-62-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 270.9°Cat760mmHg
• Flash Point: 117.6°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 0.00666mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.03±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-BROMO-2-METHYLBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-METHYLBENZYLAMINE(376646-62-7)
• EPA Substance Registry System: 4-BROMO-2-METHYLBENZYLAMINE(376646-62-7)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 376646-62-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-methylbenzylamine is a chemical compound that belongs to the class of organic compounds known as anilides. Its molecular formula is C8H10BrN and it has a molecular weight of 196.079 g/mol. 4-BROMO-2-METHYLBENZYLAMINE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in the preparation of various compounds. The chemical is a pale yellow to brown liquid with a strong, unpleasant odor. It is considered to be moderately hazardous, and proper safety precautions should be taken when handling it.

InChI:InChI=1/C8H10BrN/c1-6-4-8(9)3-2-7(6)5-10/h2-4H,5,10H2,1H3

Upstream product

• 67832-11-5 4-bromo-2-methylbenzonitrile 

Downstream Products

• 1798791-43-1 tert-butyl N-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate 
• 1352896-24-2 tert-butyl N-[(4-bromo-2-methylphenyl)methyl]carbamate 

Relevant articles and documents

3-[(1H-PYRAZOL-4-YL)OXY]PYRAZIN-2-AMINE COMPOUNDS AS HPK1 INHIBITOR AND USE THEREOF

Disclosed herein is 3- [ (1H-pyrazol-4-yl) oxy] pyrazin-2-amine compounds of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of modulating, e.g., inhibiting or treating HPK1 related disorders or diseases including cancer by using the compound disclosed herein

Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic role in autoimmune diseases. In systemic lupus erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory cytokine producti

INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, methods for use as Bruton's tyrosine kinase and methods of production.