37693-01-9

Basic information

• Product Name: CLOFOCTOL
• Synonyms: CLOFOCTOL;2-[2,4-DICHLOROBENZYL]-4-[1,1,3,3-TETRAMETHYLBUTYL]PHENOL;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)-pheno;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)phenol;α-[2,4-Dichlorophenyl]-4-[1,1,3,3-tetramethylbutyl]-o-cresol;Gramplus;Octofene
• CAS NO: 37693-01-9
• Molecular Formula: C₂₁H₂₆Cl₂O
• Molecular Weight: 365.34
• EINECS: 253-632-6
• Product Categories: OCTOPHENE
• Mol File: 37693-01-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: 78°
• Boiling Point: 447.7 °C at 760 mmHg
• Flash Point: 160.4 °C
• Appearance: /
• Density: 1.127 g/cm3
• Vapor Pressure: 1.25E-08mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: 2-8°C
• PKA: 10.09±0.45(Predicted)
• CAS DataBase Reference: CLOFOCTOL(CAS DataBase Reference)
• NIST Chemistry Reference: CLOFOCTOL(37693-01-9)
• EPA Substance Registry System: CLOFOCTOL(37693-01-9)

Safety Data

• WGK Germany: 2
• RTECS: SL0533000
• Hazardous Substances Data: 37693-01-9(Hazardous Substances Data)

Usage

Description

CLOFOCTOL, also known as clofibrate, is a synthetic compound with bacteriostatic antibiotic properties. It is effective against gram-positive bacteria and has been widely used in various applications due to its antimicrobial properties.

Uses

Used in Antimicrobial Applications:
CLOFOCTOL is used as an antibacterial agent for its bacteriostatic effects against gram-positive bacteria. It helps in controlling and preventing bacterial infections, making it a valuable component in various industries.
Used in Pharmaceutical Industry:
CLOFOCTOL is used as an active pharmaceutical ingredient in the development of medications targeting gram-positive bacterial infections. Its bacteriostatic properties make it a suitable candidate for creating effective treatments and therapies.
Used in Cosmetic Industry:
In the cosmetic industry, CLOFOCTOL is used as a preservative to prevent the growth of gram-positive bacteria, ensuring the safety and longevity of cosmetic products.
Used in Food Industry:
CLOFOCTOL is utilized as a food preservative to inhibit the growth of gram-positive bacteria, maintaining the freshness and quality of food products while extending their shelf life.
Used in Water Treatment:
CLOFOCTOL is employed in water treatment processes to control the growth of gram-positive bacteria, ensuring the safety and cleanliness of water supplies for various applications.

Originator

Octofene,Debat,France,1978

Manufacturing Process

The following were introduced into a 1 liter flask provided with a reflux condenser: 206 g (1 mol) of p-(1,1,3,3-tetramethylbutyl)-phenol, 147 g (0.75 mol) of 2,4-dichlorobenzyl chloride, 27 g (0.2 mol) of pure melted zinc chloride, and 750 ml of anhydrous chloroform. The mixture was heated to reflux for 24 hours. The chloroformic reaction mixture was washed with water, and then dried over anhydrous sodium sulfate. The chloroform was evaporated off and the oil obtained was fractionally distilled under a pressure of 0.2 mm Hg. The fraction distilling at 140°C to 160°C, being the desired product indicated above, was collected and crystallized. Yield: 94 g (32% of theory); MP 78°C (after recrystallization in petroleum ether).

Therapeutic Function

Antiinfective, Bacteriostatic

InChI:InChI=1/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3

Downstream Products

• 1357190-53-4 C₂₇H₃₄Cl₂O 
• 1357190-52-3 C₂₄H₂₈Cl₂O