37760-44-4

Basic information

• Product Name: 3-phenyl-6,10b-dihydro-5H-[1,2,4]oxadiazolo[5,4-a]isoquinoline
• CAS NO: 37760-44-4
• Molecular Weight: 250.3
• Mol File: 37760-44-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-phenyl-6,10b-dihydro-5H-[1,2,4]oxadiazolo[5,4-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-6,10b-dihydro-5H-[1,2,4]oxadiazolo[5,4-a]isoquinoline(37760-44-4)
• EPA Substance Registry System: 3-phenyl-6,10b-dihydro-5H-[1,2,4]oxadiazolo[5,4-a]isoquinoline(37760-44-4)

Safety Data

• Hazardous Substances Data: 37760-44-4(Hazardous Substances Data)

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 932-90-1 Benzaldoxime 
• 3230-65-7 3,4-dihydroisoquinoline 
• 698-16-8 benzohydroximoyl chloride 

Relevant articles and documents

Organocatalytic Oxidative Cyclization of Amidoximes for the Synthesis of 1,2,4-Oxadiazolines

Organocatalytic synthesis of bi- and tricyclic fused 1,2,4-oxadiazolines is reported. The reaction proceeds through oxidative cyclization of the corresponding amidoxime using 2,4,6-tris(4-fluorophenyl)pyrylium tetrafluoroborate (T(p-F)PPT) as the organocatalyst, and molecular oxygen as the green oxidant. During the transformation, T(p-F)PPT acts as both the electrophilic catalyst and photocatalyst, and the reaction is promoted by irradiation with visible light. The method introduced herein offers a straightforward route to the preparation of 1,2,4-oxadiazolines with different functionalities, and is highly atom economical. (Figure presented.).