37765-74-5

Basic information

• Product Name: diethyl 4-ethylbenzylmalonate
• Synonyms: diethyl 4-ethylbenzylmalonate
• CAS NO: 37765-74-5
• Molecular Weight: 278.348
• Mol File: 37765-74-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl 4-ethylbenzylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-ethylbenzylmalonate(37765-74-5)
• EPA Substance Registry System: diethyl 4-ethylbenzylmalonate(37765-74-5)

Safety Data

• Hazardous Substances Data: 37765-74-5(Hazardous Substances Data)

Upstream product

• 57825-30-6 4-ethylbenzyl bromide 
• 105-53-3 diethyl malonate 
• 768-59-2 4-ethylbenzyl alcohol 
• 996-82-7 sodium diethylmalonate 
• 1467-05-6 4-ethylbenzylchloride 

Downstream Products

• 859967-01-4 3-(4-ethyl-phenyl)-propionic acid pentyl ester 
• 180274-13-9 3-(4-ethylphenyl)propan-1-ol 
• 351014-45-4 vinyl 3-(4-ethylphenyl)propanoate 
• 64740-36-9 3-(4-ethyl-phenyl)-propionic acid 
• 351015-27-5 4-ethylbenzylmalonic acid 

Relevant articles and documents

COMPOUNDS HAVING AGONISTIC EFFECT AGAINST GPR84, PREPARATION METHOD FOR COMPOUNDS AND USE OF COMPOUNDS

The present invention relates to a class of compounds represented by the formula I, or pharmaceutically acceptable salts thereof, methods for their preparation, and application as small molecule tools that function as GPR84 agonists, and their use in preparing a medicament for the treatment of septicemia.

The effect of vinyl esters on the enantioselectivity of the lipase-catalysed transesterification of alcohols

The enantioselectivity of the lipase from Pseudomonas cepacia (PCL) in the transesterification of 2-phenyl-1-propanol 1 was studied using a series of vinyl 3-arylpropanoates as acyl donors. The most enantioselective transesterification reaction of the alcohol was attained by using vinyl 3-(p-iodophenyl)- or 3-(p-trifluoromethylphenyl)propanoates, with enantiomer ratios, E, of 116 and 138, respectively. Vinyl 3-phenylpropanoate was also effective for the resolution of 1 mediated by lipases from P. fluorescens and porcine pancreas and for the PCL-catalysed transesterification of several 2-phenyl-1-alkanols. The enantiomeric resolution of 1 was practically carried out by the first enantioselective transesterification using PCL and vinyl 3-(p-iodophenyl)propanoate to afford (R)-1 and then the enantioselective hydrolysis of the resultant ester to afford (S)-1.