37784-22-8

Basic information

• Product Name: (R)-(-)-N-acetyl-α-(acetoxyphenyl)glycine
• CAS NO: 37784-22-8
• Molecular Weight: 251.239
• Mol File: 37784-22-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-(-)-N-acetyl-α-(acetoxyphenyl)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-N-acetyl-α-(acetoxyphenyl)glycine(37784-22-8)
• EPA Substance Registry System: (R)-(-)-N-acetyl-α-(acetoxyphenyl)glycine(37784-22-8)

Safety Data

• Hazardous Substances Data: 37784-22-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 6324-01-2 p-hydroxyphenylglycine 
• 22818-40-2 D-4-hydroxyphenylglycine 

Downstream Products

• 37784-23-9 N-acetyl-(R)-2-(4-hydroxyphenyl)glycine 

Relevant articles and documents

-

Treatment of the readily available (S)-(+) and (R)-(-) enantiomers of 2-aminobutan-1-ol 1 with sodium hydride followed by benzyl chloride, or a substituted benzyl halide, afforded the corresponding O-benzyl bases 4-7 in good yields. These new bases are recommended for the large scale resolution of racemic acids. For instance, they proved efficient for the practical resolutions of α-methylsuccinic acid (±)-9, N-acetylphenylglycine (±)-11, N-acetyl-(4-hydroxyphenyl) glycine (±)-14 and N-chloroacetyl-(4-hydroxyphenyl) glycine (±)-15.