37786-00-8 Usage
Type
Synthetic analog
Explanation
11-Deoxy Prostaglandin E1 is a synthetic version of the naturally occurring prostaglandin E1.
Explanation
It is involved in various physiological processes in the body.
Explanation
It is used in medicine for its ability to widen blood vessels and prevent blood clots.
Explanation
It is useful in treating these conditions due to its vasodilatory and antiplatelet properties.
Explanation
It works by causing the smooth muscle cells in blood vessels to relax, leading to increased blood flow and improved circulation.
Explanation
It inhibits the clumping together of platelets, reducing the risk of blood clots.
Explanation
11-Deoxy Prostaglandin E1 has important therapeutic applications in treating disorders related to the heart, blood vessels, and male reproductive system.
Function
Hormone-like substance
Medical use
Vasodilatory and antiplatelet effects
Treatment of conditions
Peripheral vascular disease and erectile dysfunction
Mechanism of action
Relaxing smooth muscle cells in blood vessels
Inhibition
Platelet aggregation
Therapeutic applications
Cardiovascular and urological disorders
Check Digit Verification of cas no
The CAS Registry Mumber 37786-00-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,7,8 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37786-00:
(7*3)+(6*7)+(5*7)+(4*8)+(3*6)+(2*0)+(1*0)=148
148 % 10 = 8
So 37786-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H34O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,16-18,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
37786-00-8Relevant articles and documents
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF &α-HOMOANALOGS OF 11-DESOXYPROSTAGLANDIN E1
Bagaeva, S. G.,Valeev, F. A.,Miftakhov, M. S.,Lazareva, D. N.,Davydova, V. A.,Tolstikov, G. A.
, p. 249 - 253 (2007/10/02)
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TOTAL SYNTHESIS AND PROPERTIES OF PROSTAGLANDINS. VII.* ISOMERIZATION OF(+/-)-11-DEOXYPROSTAGLANDIN-E1
Freimanis, Ya. F.,Korits, V. R.,Sokolov, G. P.,Shatts, V. D.,Sakhartova, O. V.,et al.
, p. 1940 - 1946 (2007/10/02)
Under equilibrium conditions (+/-)-11-deoxyprotaglandin-E1 exists in the form of a mixture of the 8,12-cis and 8,12-trans-isomers with a preponderance of the thermodynamically more favorable trans isomer.The 8-epimers can be converted into each other and are separated preparatively by crystallization or by chromatogratic methods.During exhaustive silylation of the isomers the same 1,9,15-tris-O-silyl derivative with an enolic C=C double bond at positions 8,9 is formed.
Prostaglandins and congeners. 20. Synthesis of prostaglandins via conjugate addition of lithium trans-1-alkenyltrialkylalanate reagents. A novel reagent for conjugate 1,4-additions
Bernady,Floyd,Poletto,Weiss
, p. 1438 - 1446 (2007/10/06)
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