3779-31-5Relevant articles and documents
Selective Synthesis of β-Ketonitriles via Catalytic Carbopalladation of Dinitriles
Zeng, Ge,Liu, Jichao,Shao, Yinlin,Zhang, Fangjun,Chen, Zhongyan,Lv, Ningning,Chen, Jiuxi,Li, Renhao
, p. 861 - 867 (2021/01/09)
A practical, convenient, and highly selective method of synthesizing β-ketonitriles from the Pd-catalyzed addition of organoboron reagents to dinitriles has been developed. This method provides excellent functional-group tolerance, a broad scope of substrates, and the convenience of using commercially available substrates. The method is expected to show further utility in future synthetic procedures.
Solvent-free preparation method of di-substituted malononitrile derivative
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Paragraph 0045; 0048-0053, (2019/05/11)
The invention relates to a solvent-free preparation method of a di-substituted malononitrile derivative. The solvent-free preparation method comprises: 1, adding malononitrile, aromatic aldehyde and dihydropyridine ester to a reaction test tube according
A one-pot electrophilic cyanation–functionalization strategy for the synthesis of disubstituted malononitriles
Mills, L. Reginald,Rousseaux, Sophie A.L.
, p. 4298 - 4306 (2019/05/22)
Malononitriles are valuable synthetic intermediates for many applications, including the synthesis of herbicides and other biologically active molecules, and the synthesis of chiral ligands for asymmetric catalysis. This article describes the development of a procedure for the conversion of primary nitriles to malononitriles using dimethylmalononitrile, a commercial, non-toxic, carbon-bound source of electrophilic cyanide. This procedure avoids the use of toxic cyanide or malononitrile as a starting material. This protocol is further applied to the dicyanation of benzyl Grignard reagents, generated from benzyl bromides, yielding fully functionalized malononitriles from a nitrile-free precursor.