3782-84-1

Basic information

• Product Name: 3-(Trimethylsiloxy)benzoic acid trimethylsilyl ester
• Synonyms: 3-(Trimethylsiloxy)benzoic acid trimethylsilyl ester
• CAS NO: 3782-84-1
• Molecular Formula: C₁₃H₂₂O₃Si₂
• Molecular Weight: 282.48
• Mol File: 3782-84-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Trimethylsiloxy)benzoic acid trimethylsilyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Trimethylsiloxy)benzoic acid trimethylsilyl ester(3782-84-1)
• EPA Substance Registry System: 3-(Trimethylsiloxy)benzoic acid trimethylsilyl ester(3782-84-1)

Safety Data

• Hazardous Substances Data: 3782-84-1(Hazardous Substances Data)

Upstream product

• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 99-06-9 3-Carboxyphenol 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 75-77-4 chloro-trimethyl-silane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 81769-81-5 3-<(3,5-di-tert-butyl-4-hydroxyphenyl)(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)methyl>-phenol 
• 81769-93-9 1-<(3,5-di-tert-butyl-4-hydroxyphenyl)(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)methyl>-3-<(2,5-dihydro-2,2,5,5-tetramethylpyrrol-1-yloxy-3-yl)(carbonyloxy)>benzene 
• 1637-75-8 (3-hydroxybenzamido)acetic acid 
• 79302-65-1 3-(trimethylsiloxy)phenyl isocyanate 
• 79314-29-7 4-adipoyl-2-(3-trimethylsiloxyphenyl)-1,3,4-oxadiazol-5-one 
• 79302-70-8 2-(3-trimethylsiloxyphenyl)-4-trimethylsilyl-1,3,4-oxadiazol-5-one 
• 79302-54-8 N-(3-trimethylsiloxybenzoyl)-caprolactam 
• 79302-73-1 1-(3-Trimethylsiloxybenzoyl)oxazolidin-2-one 
• 79302-52-6 1-(3-Trimethylsilanyloxy-benzoyl)-pyrrolidin-2-one 
• 79302-51-5 N-(3-hydroxybenzoyl)-caprolactam 
• 79302-74-2 2-(3-trimethylsiloxyphenyl)-1,3,4-oxadiazol-5-one 
• 79302-75-3 1-(3-hydroxybenzoyl)oxazolidin-2-one 
• 79314-28-6 C₁₃H₂₃NO₂Si₂ 
• 79302-50-4 1-(3-hydroxybenzoyl)-2-pyrrolidinone 

Relevant articles and documents

Development of a QuEChERS-Based Stable-Isotope Dilution LC-MS/MS Method to Quantitate Ferulic Acid and Its Main Microbial and Hepatic Metabolites in Milk

Forage plants of the Poaceae family are grown as pasturage or used for the production of hay, straw, corn stover, etc. Although ferulic acid contents of grasses are generally high, the amount of ingested ferulic acid differs depending on the type of forage, resulting in varying contents of ferulic acid and its microbial and hepatic metabolites in milk. Concentrations and patterns of these metabolites may be used as markers to track different forages in livestock feeding. Therefore, we developed a stable isotope dilution assay to quantitate ferulic acid, 12 ferulic acid-based metabolites, p-coumaric acid, and cinnamic acid in milk. Because most analytes were not commercially available as stable isotope labeled standard compounds, they were synthesized as 13C- or deuterium-labeled standard compounds. A modification of the QuEChERS method, a Quick, Easy, Cheap, Effective, Rugged, and Safe approach usually applied to analyze pesticides in plant-based products, was used to extract the phenolic acids from milk. Determination was carried out by LC-ESI-MS/MS in scheduled multiple reaction monitoring modus. By using three different milk samples, the applicability of the validated approach was demonstrated.

Syntheses and Reactions of (Trimethylsiloxy)benzoyl Chlorides

The (trimethylsiloxy)benzoyl chlorides 1-7 are easily to obtain under mild conditions from silylated hydroxybenzoic acids by means of thionyl chloride.Whereas these acid chlorides are stable at room temperature, they undergo condensation polymerisation at temperatures above 100 deg C.Reactions with various nucleophils, such as thioalcohols, phenols, amines, N,O-bis(silylated)amino acids and N-silylated lactams were investigated.With hexamethyldisilazane and thionyl chloride the (trimethylsiloxy)benzonitriles 21, 22 are accessible, and by means of trimethylsilylazide the (trimethylsiloxy)phenyl isocyanates 23-25 were obtained.Conversion with phenyl carbazate and subsequent silylation lead to the 2-(trimethylsiloxy)phenyl-1,3,4-oxadiazol-5-ones 27a-c.