378236-46-5

Basic information

• Product Name: (R)-(C₁₀H₇)CHMeNCH(C₆H₄F-2)
• CAS NO: 378236-46-5
• Molecular Weight: 277.341
• Mol File: 378236-46-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-(C₁₀H₇)CHMeNCH(C₆H₄F-2)(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(C₁₀H₇)CHMeNCH(C₆H₄F-2)(378236-46-5)
• EPA Substance Registry System: (R)-(C₁₀H₇)CHMeNCH(C₆H₄F-2)(378236-46-5)

Safety Data

• Hazardous Substances Data: 378236-46-5(Hazardous Substances Data)

Upstream product

• 3886-70-2 (R)-1-(1-Naphthyl)ethylamine 
• 446-52-6 2-Fluorobenzaldehyde 

Relevant articles and documents

Stereoselective oxidative addition of methyl iodide to chiral cyclometallated platinum(II) compounds derived from (R)-(+)-1-(1-naphthylethylamine). Crystal structure of [PtMe{3-(R)-(C10H7)CHMeNCHC4H 2S}PPh3]

The reaction of 3-(R)-(C10H7)CHMeNCHC4H3S (2a) with [Pt2Me4(μ-SMe2)2] in acetone gave the new chiral cyclometallated platinum(II) compound [PtMe{3-(R)-(C10H7)CHMeNCHC4H 2S}SMe2] (3a). Addition of PPh3 produced compound [PtMe{3-(R)-(C10H7)CHMeNCHC4H 2S}PPh3] (4a) which was characterized by X-ray diffraction methods. While oxidative addition of methyl iodide to 3a gave two pairs of diastereomers, the analogous reaction for 4a produced only one diastereomer of the platinum(IV) compound [PtMe2I{3-(R)-(C10H7)CHMeNCHC4H 2S}PPh3] (7a). Subsequent isomerization of the resulting platinum(IV) compound gave a new pair of diastereomers in relative amounts 90 and 10%. Analogous proportions of final diastereomers were obtained for the oxidative addition of methyl iodide to the new chiral compounds [PtMe{3-(R)-(C10H7)CHMeNCHAr}PPh3] (Ar=C6H4 (4b), 2-FC6H3 (4c), 2-CF3C6H3 (4d)). The reaction of [Pt2Me4(μ-SMe2)2] with imines (R)-(C10H7)CHMeNCH(2-BrC6H4) (2e) and (R)-(C10H7)CHMeNCH(2,6-Cl2C6H 3) (2f) produced intramolecular oxidative addition to yield platinum(IV) compounds with some degree of stereoselectivity.