37856-17-0

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-(4-methoxyphenyl)-2-phenyl-
• Synonyms: 3-(4-methoxy-phenyl)-2-phenyl-3H-quinazolin-4-one;3-(4-Methoxy-phenyl)-2-phenyl-3H-chinazolin-4-on;3-(4-methoxyphenyl)-2-phenylquinazolin-4(3H)-one
• CAS NO: 37856-17-0
• Molecular Formula: C21H16N2O2
• Molecular Weight: 328.37
• Mol File: 37856-17-0.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-(4-methoxyphenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-(4-methoxyphenyl)-2-phenyl-(37856-17-0)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-(4-methoxyphenyl)-2-phenyl-(37856-17-0)

Safety Data

• Hazardous Substances Data: 37856-17-0(Hazardous Substances Data)

Upstream product

• 579-93-1 2-(Benzoylamino)benzoic Acid 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 1402939-08-5 (Z)-methyl N-2-bromophenylbenzimidate 
• 104-94-9 4-methoxy-aniline 
• 100-52-7 benzaldehyde 
• 20878-54-0 2-amino-N-(4-methoxyphenyl)benzamide 
• 108-88-3 toluene 
• 118-48-9 isatoic anhydride 
• 611-71-2 MANDELIC ACID 
• 36684-49-8 2-iodo-N-(4-methoxyphenyl)benzamide 
• 100-46-9 benzylamine 
• 98-88-4 benzoyl chloride 
• 22979-83-5 2-nitro-N-(4-methoxyphenyl)benzamide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 52458-01-2 4,4-di-naphthalen-1-yl-2-phenyl-4H-benzo[d][1,3]oxazine 

Relevant articles and documents

α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and other N-heterocyclesviadecarboxylative oxidative annulation reaction

A metal-free and efficient procedure for the synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and indolo[1,2-a]quinoxaline has been developed. The key features of our method include thein situgeneration of aldehyde from α-hydroxy acid in the presence of TBHP (tert-butyl hydrogen peroxide), and further condensation with various amines, followed by intramolecular cyclization and subsequent oxidation to afford the corresponding quinoxalines, quinazolinones derivatives in moderate to high yields.

One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies

A metal-free and oxidant-free method for the one-pot preparation of quinazolin-4(3H)-ones enabled by electrochemical oxidation is described. Together with 2-aminobenzamides, a variety of aldehydes were successfully applied to an acid-catalyzed annulation and direct anodic oxidation cascade, affording structurally diverse quinazoline-4(3H)-ones in good to excellent yields. Additionally, certain alcohols can be directly applied instead of the corresponding aldehydes to achieve the same final products with the assistance of an electrolysis mediator (TEMPO). The reaction mechanism was carefully examined and the results strongly suggest that the direct and indirect oxidation go through different pathways. As an efficient and environmentally friendly access to a broad range of quinazolin-4(3H)-ones, the synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive mackinazolinone and truncated erlotinib. (Figure presented.).

Efficient and practical one-pot route to synthesise quinazolin4(3H)-ones using trifluoromethanesulfonic anhydride and 2-chloropyridine

An effective, novel and rapid one-pot three-component route to quinazolin-4(3H)-ones from commercially available starting materials is described. Isatoic anhydride reacts with acyl chlorides and different amines using a combination of trifluoromethanesulf