37864-30-5

Basic information

• Product Name: (4-methyl-2-quinolinyl)(phenyl)methanone
• Synonyms: (4-methyl-2-quinolinyl)(phenyl)methanone
• CAS NO: 37864-30-5
• Molecular Formula: C₁₇H₁₃NO
• Molecular Weight: 247.29122
• Mol File: 37864-30-5.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-methyl-2-quinolinyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methyl-2-quinolinyl)(phenyl)methanone(37864-30-5)
• EPA Substance Registry System: (4-methyl-2-quinolinyl)(phenyl)methanone(37864-30-5)

Safety Data

• Hazardous Substances Data: 37864-30-5(Hazardous Substances Data)

Upstream product

• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 7473-98-5 2-hydroxy-2-methylpropiophenone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 52562-19-3 2-isopropenylaniline 
• 108-88-3 toluene 
• 100-52-7 benzaldehyde 
• 53599-95-4 N-benzoyl-4-methyl-1,2-dihydroquinaldonitrile 
• 611-73-4 Benzoylformic acid 

Relevant articles and documents

Visible-Light-Induced Decarboxylative Acylation of Pyridine N-Oxides with α-Oxocarboxylic Acids Using Fluorescein Dimethylammonium as a Photocatalyst

Herein, the development of a visible-light-induced catalytic system to achieve the decarboxylative acylation of pyridine N-oxides with α-oxocarboxylic acids, at room temperature and using the organic dye fluorescein dimethylammonium as a new type of photocatalyst, is reported. A series of 2-arylacylpyridine N-oxides were selectively synthesized in moderate to good yields by controlling the polarity of the reaction solvent. The developed strategy was successfully applied in the synthesis of an important intermediate of the drug, acrivastine, on a gram scale. Notably, this is the first time that fluorescein dimethylammonium has been used to catalyze the Minisci-type C?H decarboxylative acylation reaction. The mechanism of decarboxylative acylation was studied by capturing adducts of acyl radicals and 1,1-diphenylethylene to confirm a radical mechanism. The disclosed catalytic system provides a green synthetic strategy for decarboxylative acylation without the use of additional oxidants or metal catalysts. (Figure presented.).

RuII-Catalyzed/NH2-Assisted Selective Alkenyl C-H [5 + 1] Annulation of Alkenylanilines with Sulfoxonium Ylides to Quinolines

A novel ruthenium-catalyzed [5 + 1] annulation of 2-alkenylanilines with sulfoxonium ylides was developed for the rapid assembly of highly functionalized quinolines. This new catalytic process employs challenging but synthetically ideal free amino functionality to achieve alkenyl C-H activation with sulfoxonium ylides as one-carbon coupling partners. Various 2-acylquinolines could be obtained with good yields and excellent functional group tolerance. Moreover, the potential synthetic application of this methodology was exemplified by several chemical transformations.

Synthesis method of acylated quinoline or isoquinoline derivative

The invention discloses a synthesis method of an acylated quinoline or isoquinoline derivative, belongs to the field of organic synthesis, and aims to solve the problems of complicated reaction, severe conditions and low environmental friendliness in the