379-95-3 Usage
Description
DIMETHYL DIFLUOROMALONATE, also known as diethyl difluoromalonate, is an important raw material and intermediate used in various industries, including organic synthesis, pharmaceuticals, and agrochemicals. It is a colorless to pale yellow transparent liquid with properties that make it suitable for use as a polymerization medium and a raw material in the production of various compounds.
Uses
Used in Organic Synthesis:
DIMETHYL DIFLUOROMALONATE is used as a key intermediate for the synthesis of various organic compounds, contributing to the development of new materials and chemical products.
Used in Pharmaceutical Industry:
DIMETHYL DIFLUOROMALONATE is used as a building block in the development of pharmaceuticals, playing a crucial role in the creation of new drugs and therapies.
Used in Agrochemicals:
DIMETHYL DIFLUOROMALONATE is used as a starting material in the production of agrochemicals, such as pesticides and herbicides, helping to improve agricultural productivity and crop protection.
Used in Polymer Synthesis:
DIMETHYL DIFLUOROMALONATE is used as a polymerization medium for the synthesis of polymers, enabling the creation of new types of plastics, resins, and other polymeric materials.
Used in Surfactant Production:
DIMETHYL DIFLUOROMALONATE is used as a raw material in the manufacture of surfactants, which are essential components in the production of detergents, emulsifiers, and other products.
Used in Corrosion Inhibitors:
DIMETHYL DIFLUOROMALONATE is used in the production of corrosion inhibitors, helping to protect metals and other materials from degradation and wear.
Used in Plastics, Paints, and Coatings:
DIMETHYL DIFLUOROMALONATE can be copolymerized with other monomers to produce synthetic resins, which are used in the manufacturing of plastics, paints, and coatings, enhancing their properties and performance.
Precautions
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.
Check Digit Verification of cas no
The CAS Registry Mumber 379-95-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,7 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 379-95:
(5*3)+(4*7)+(3*9)+(2*9)+(1*5)=93
93 % 10 = 3
So 379-95-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H6F2O4/c1-10-3(8)5(6,7)4(9)11-2/h1-2H3
379-95-3Relevant articles and documents
SYNTHESIS OF N-SUBSTITUTED DIAMIDES OF DIFLUOROMALONIC AND TETRAFLUOROSUCCINIC ACIDS AND X-RAY STRUCTURE OF THE N,N'-BIS(2-CARBOXYETHYL)DIAMIDE OF TETRAFLUOROSUCCINIC ACID
Fokin, A. V.,Martynov, I. V.,Chekhlov, A. N.,Rapkin, A. I.,Tatarinov, A. S.
, p. 329 - 332 (1989)
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Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation
Chung, Cheol K.,Clagg, Kyle,Dalziel, Michael E.,Fettes, Alec,Finet, Laure,Gosselin, Francis,Jenny, Christian,Kammerer, Michael,Lim, Ngiap-Kie,Mack, Kyle A.,McClory, Andrew,Wuitschik, Georg,Xu, Jie,Zhang, Haiming,Angelaud, Rémy
, (2021/11/24)
GDC-9545 is a selective estrogen receptor degrader that is being developed as a treatment for ER+/HER2- breast cancer. A robust, convergent manufacturing process for GDC-9545 was developed. The process features a Wenker aziridine synthesis to produce the key starting material tryptamine 11, a highly efficient C-N coupling between aminoazetidine 9 and 2,6-difluoro-4-bromobenzaldehyde diethyl acetal (33) to construct key intermediate 10, and a crystallization-driven diastereoselective Pictet-Spengler reaction to furnish the active pharmaceutical ingredient GDC-9545·tartrate.
Perfluoroepoxycarboxylates. Preparation and some properties
Zapevalov,Filyakova,Kodess
, p. 1113 - 1116 (2007/10/03)
Perfluoroepoxycarboxylates were obtained by oxidation with molecular oxygen of esters of unsaturated perfluoroepoxycarboxylic acids CF2=CF(CF2)nCO2CH3 under UV irradiation. The isomeric transformations and thermal stability of the methyl pentafluoro-3,4-epoxybutanate were studied. In the reaction of the above compound with Et3N was obtained methyl tetrafluoro-3-fluoroformylpropanate, and with SbF5 on graphite arised methyl pentafluoroacetate.
