37901-50-1

Basic information

• Product Name: ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate
• Synonyms: ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate
• CAS NO: 37901-50-1
• Molecular Weight: 245.281
• Mol File: 37901-50-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate(37901-50-1)
• EPA Substance Registry System: ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate(37901-50-1)

Safety Data

• Hazardous Substances Data: 37901-50-1(Hazardous Substances Data)

Upstream product

• 38047-06-2 ethyl 5-methyl-1-(2-nitrophenyl)-1H-pyrazole-3-carboxylate 
• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 
• 615-79-2 ethyl 2,4-diketopentanoate 

Relevant articles and documents

Synthesis, characterization and antibacterial activity of novel Schiff bases

The present work describes the synthesis of novel Schiff bases (8.1-8.9) in five steps from diethyl oxalate and acetone as starting materials. Condensation of ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate (6) with aromatic and heteroaromatic aldehydes (7.1-7.9) in presence of sodium sulphate at 50 °C in ethanol gave the corresponding imine derivatives (8.1-8.9) in quantitative yields. The structure of these compounds was determined by 1H NMR, mass and IR spectral data. These Schiff's bases were further evaluated for antibacterial activity against the selected Gram-positive and Gram-negative bacteria pathogens. The antibacterial activity data revealed that Schiff base embedded with heteroaromatic ring was found to exhibit good antibacterial activity than the aromatic ring.