37921-15-6

Basic information

• Product Name: 1-methyl-4-(4-nitrophenyl)-1H-pyrazole
• Synonyms: 1-methyl-4-(4-nitrophenyl)-1H-pyrazole
• CAS NO: 37921-15-6
• Molecular Weight: 203.2
• Mol File: 37921-15-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-methyl-4-(4-nitrophenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-(4-nitrophenyl)-1H-pyrazole(37921-15-6)
• EPA Substance Registry System: 1-methyl-4-(4-nitrophenyl)-1H-pyrazole(37921-15-6)

Safety Data

• Hazardous Substances Data: 37921-15-6(Hazardous Substances Data)

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 
• 586-78-7 para-nitrophenyl bromide 
• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 
• 171364-83-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 114474-26-9 4-(4-nitrophenyl)-1H-pyrazole 
• 74-88-4 methyl iodide 
• 24067-17-2 4-nitrophenylboronic acid 

Downstream Products

• 1079178-22-5 4-(1-methyl-1H-pyrazol-4-yl)aniline 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING

The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

CYCLIN-DEPENDENT KINASE INHIBITORS

Described herein are compounds and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, methods of treatment, and medical uses. The compounds described herein are modulators of cyclin-dependent kinases, and are useful in the treatment or alleviation of protein kinase associated disorders, including cancer, infectious diseases, autoimmune diseases, or cardiovascular diseases.

Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds. In contrast to 3 or 5-aryl pyrazole, the preparation of 4-aryl pyrazole is fairly rare. Utilizing microwave irradiation, the synthesis of 4-substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates. The remarkable advantages of this method are mild reaction conditions, simple operation, high yield, and short reaction time. Product structures were identified by MS, 1H NMR, 13C NMR, and elemental analysis.