379691-85-7Relevant articles and documents
Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent α4β1 integrin antagonists
Duplantier, Allen J.,Beckius, Gretchen E.,Chambers, Robert J.,Chupak, Louis S.,Jenkinson, Teresa H.,Klein, Anne S.,Kraus, Kenneth G.,Kudlacz, Elizabeth M.,McKechney, Michael W.,Pettersson, Martin,Whitney, Carrie A.,Milici, Anthony J.
, p. 2593 - 2596 (2007/10/03)
A series of isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives derived from LDV was found to be a potent antagonist of the α4β1 integrin. The synthesis and SAR leading up to 3-[3-(1-{2-[3-methoxy-4-(3-o-tolyl-ureido)-pheny