380383-75-5Relevant articles and documents
Biarylhydrazine compounds and their adducts and applications in the preparation of antitumor drugs
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Paragraph 0058; 0068; 0069; 0159; 0166; 0167, (2022/03/27)
The present invention discloses a biarylhydrazine compound and its application in the preparation of antitumor drugs, the structure of the arylhydrazine compound as shown in formula I, the adduct is a biarylhydrazine compound on the hydrazine group plus benzyloxycarbonyl glycyl prolyl. The anticancer activity of the biarylhydrazine compounds of the present invention is superior to that of the existing positive control drug procarbazine; its Z-GP adduct can significantly reduce in vitro toxicity and in vivo toxicity to normal cells, and can be excised by FΑP-α enzyme specific hydrolysis in vivo (Z-GP) to release hydrolysate products; its Z-GP adduct can significantly inhibit tumor growth in tumor-bearing nude mice and reduce toxicity to non-target organs.
Starazo triple switches - synthesis of unsymmetrical 1,3,5-tris(arylazo)benzenes
Heindl, Andreas H.,Wegner, Hermann A.
supporting information, p. 22 - 31 (2020/03/27)
Multistate switches allow to drastically increase the information storage capacity and complexity of smart materials. In this context, unsymmetrical 1,3,5-tris(arylazo)benzenes - 'starazos' - which merge three photoswitches on one benzene ring, were succe
Copper(I)-picolinic acid catalyzed N-arylation of hydrazides
Lam, Miu Suen,Lee, Hang Wai,Chan, Albert S.C.,Kwong, Fuk Yee
supporting information; scheme or table, p. 6192 - 6194 (2009/04/05)
An efficient copper-catalyzed carbon-nitrogen bond formation is described. The copper(I) complex with commercially available 2-picolinic acid ligand was found to be effective in N-arylation of N-Boc-hydrazine. This methodology offers a regioselective N-ar