3804-89-5

Basic information

• Product Name: 2'-(sulphomethyl)isonicotinohydrazide, monosodium salt
• Synonyms: 2'-(sulphomethyl)isonicotinohydrazide, monosodium salt;Isoniazid sodium methanesulfonate;Neoiscotin;Neotizide sodium;N'-Sodiooxysulfonylmethylisonicotinic hydrazide;Methanesulfonate sodium
• CAS NO: 3804-89-5
• Molecular Formula: C₇H₈N₃O₄S*Na
• Molecular Weight: 253.21089
• EINECS: 223-275-0
• Mol File: 3804-89-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.537g/cm³
• CAS DataBase Reference: 2'-(sulphomethyl)isonicotinohydrazide, monosodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-(sulphomethyl)isonicotinohydrazide, monosodium salt(3804-89-5)
• EPA Substance Registry System: 2'-(sulphomethyl)isonicotinohydrazide, monosodium salt(3804-89-5)

Safety Data

• Hazardous Substances Data: 3804-89-5(Hazardous Substances Data)

Usage

Description

2'-(sulphomethyl)isonicotinohydrazide, monosodium salt is a chemical compound that consists of a monosodium salt form of 2'-(sulphomethyl)isonicotinohydrazide. It is a derivative of isonicotinohydrazide and is known for its unique chemical properties.
Used in Fluorescence Detection:
2'-(sulphomethyl)isonicotinohydrazide, monosodium salt is used as a fluorescence dye for the selective detection of silver ions in biological and environmental samples.
Used in Pharmaceutical Industry:
2'-(sulphomethyl)isonicotinohydrazide, monosodium salt is used as a precursor for the synthesis of various drugs and drug candidates in the pharmaceutical industry.
Used in Materials Science:
2'-(sulphomethyl)isonicotinohydrazide, monosodium salt is being explored for its potential use in materials science due to its unique chemical properties.
Used in Chemical Sensors:
2'-(sulphomethyl)isonicotinohydrazide, monosodium salt is also being explored for its potential use in the development of chemical sensors.

Upstream product

• 54-85-3 isoniazid 
• 50-00-0 formaldehyd 

Relevant articles and documents

Hydrophobic ion pairing of isoniazid using a prodrug approach

Inhalation therapy for infectious lung diseases, such as tuberculosis, is currently being explored, with microspheres being used to target alveolar macrophages. One method of drug encapsulation into polymeric microspheres to form hydrophobic ion-paired (HIP) complexes, and then coprecipitate the complex and polymer using supercritical fluid methodology. For the potent antituberculosis drug, isoniazid (isonicotinic acid hydrazide, INH), to be used in this fashion, it was modified into an ionizable form suitable for HIP. The charged prodrug, sodium isoniazid methanesulfonate (Na-INHMS), was then ion paired with hydrophobic cations, such as alkyltri-methylammonium or tetraalkylammonium. The logarithms of the apparent partition coefficients (log P′) of various HIP complexes of INHMS display a roughly linear relationship with the numbers of carbon atoms in the organic counterions. The water solubility of the tetraheptylammonium-INHMS complex is about 220-fold lower than that of Na-INHMS, while the solubility in dichloromethane exceeds 10 mg/mL, which is sufficient for microencapsulation of the drug into poly(lactide) microspheres. The actual logarithm of the dichloromethane/water partition coefficient (log P) for tetraheptylammonium-INHMS is 1.55, compared to a value of - 1.8 for the sodium salt of INHMS. The dissolution kinetics of the tetraheptylammonium-INHMS complex in 0.9% aqueous solutions of NaCl was also investigated. Dissolution of tetraheptylammonium-INHMS exhibited a first-order time constant of about 0.28 min-1, followed by a slower reverse ion exchange process to form Na-INHMS. The half-life of this HIP complex is on the order of 30 min, making the enhanced transport of the drug across biological barriers possible. This work represents the first use of a prodrug approach to introduce functionality that would allow HIP complex formation for a neutral molecule.