380430-53-5 Usage
Description
2-Ethoxycarbonylbenzeneboronic acid is an organic compound with the molecular formula C8H9BO4. It is a white crystalline solid that is soluble in water and has a characteristic aromatic smell. 2-Ethoxycarbonylbenzeneboronic acid is known for its reactivity and is commonly used as a building block in the synthesis of various organic molecules, particularly in the field of pharmaceuticals and materials science.
Uses
Used in Chemical Synthesis:
2-Ethoxycarbonylbenzeneboronic acid is used as a reactant for the synthesis of various organic compounds through different chemical reactions. It serves as a versatile intermediate in the preparation of complex molecules, such as pharmaceuticals, agrochemicals, and advanced materials.
Used in Suzuki Reaction:
In the field of organic chemistry, 2-Ethoxycarbonylbenzeneboronic acid is used as a reactant for the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds. This reaction is particularly useful in the synthesis of embelin derivatives, which have potential applications in the pharmaceutical industry.
Used in Cross Metathesis:
2-Ethoxycarbonylbenzeneboronic acid is also utilized in cross metathesis reactions, which are essential for the synthesis of complex organic molecules. This reaction type is valuable in the preparation of various compounds, including those with potential applications in the pharmaceutical and materials science industries.
Used in Asymmetric Cyclopropanation:
2-Ethoxycarbonylbenzeneboronic acid is used as a reactant in the asymmetric cyclopropanation of alkenes with di-Me diazomalonate, catalyzed by chiral diene-rhodium complexes. This reaction is crucial for the synthesis of optically active compounds, which are essential in the development of enantiomerically pure pharmaceuticals.
Used in the Preparation of Phenylalanines:
2-Ethoxycarbonylbenzeneboronic acid is used as a reactant in the preparation of phenylalanines, which serve as selective AMPAand kainate receptor ligands. These ligands are vital in the study of the central nervous system and the development of drugs targeting neurological disorders.
Used in the Preparation of Aryl Pyrazinones:
2-Ethoxycarbonylbenzeneboronic acid is used in the preparation of aryl pyrazinones via microwave-assisted palladium-catalyzed arylation of resin-supported pyrazinones under simultaneous cooling conditions. Aryl pyrazinones are important building blocks in the synthesis of various pharmaceuticals and agrochemicals.
Used in the Regioselective Preparation of (Aryl)hydroxyquinolines:
2-Ethoxycarbonylbenzeneboronic acid is used as a reactant in the regioselective preparation of (aryl)hydroxyquinolines via Suzuki-Miyaura cross-coupling with chloro(tosyloxy)quinoline under anhydrous conditions, followed by nucleophilic deprotection of the tosyl group. These (aryl)hydroxyquinolines are valuable intermediates in the synthesis of various biologically active compounds, including potential drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 380430-53-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,0,4,3 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 380430-53:
(8*3)+(7*8)+(6*0)+(5*4)+(4*3)+(3*0)+(2*5)+(1*3)=125
125 % 10 = 5
So 380430-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BO4/c1-2-14-9(11)7-5-3-4-6-8(7)10(12)13/h3-6,12-13H,2H2,1H3
380430-53-5Relevant articles and documents
Indeno[1,2-b]fluorene-Based [2,2]Cyclophanes with 4n/4n and 4n/[4n+2] π Electrons: Syntheses, Structural Analyses, and Excitonic Coupling Properties
Wang, Chi-Shin,Wei, Yu-Chen,Chang, Kai-Hsin,Chou, Pi-Tai,Wu, Yao-Ting
supporting information, p. 10158 - 10162 (2019/06/25)
Indeno[1,2-b]fluorene-based [2,2]cyclophanes with 4n/4n and 4n/[4n+2] π-electron systems were prepared, and their structures were identified by X-ray crystallography. With short π–π distances around 3.0 ?, [2.2](5,11)indeno[1,2-b]fluorenophane and its pre
